Document Detail

Exercise cardiovascular responses to gallopamil in ischemic heart disease.
MedLine Citation:
PMID:  1937985     Owner:  NLM     Status:  MEDLINE    
RESULTS: anginal attacks were reduced to a similar degree by gallopamil (2.1 +/- 1/week versus 5.8 +/- 2.8/week during placebo, p less than 0.01) and diltiazem (2.0 +/- 0.8/week versus 5.8 +/- 2.8/week during placebo, P less than 0.01). At rest, gallopamil caused a significant decrease in heart rate and a slight fall in systemic vascular resistance. Cardiac index rose during exercise and was higher with respect to placebo at peak exercise (6.7 vs 5.6 l/min/m2, P less than 0.05). As a consequence, stroke volume index and stroke work index both increased at maximum workload (P less than 0.05). Compared to placebo, exercise time was significantly improved by gallopamil (+50%, P less than 0.02) and diltiazem (+38%, P less than 0.05). Likewise, time to onset of ST-segment depression was prolonged by 70% with gallopamil (P less than 0.01) and by 64% with diltiazem (P less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
P Terrosu; G V Ibba; R Pes; G M Contini; A Delpini; V Franceschino; D Fantoccoli; M Magri
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  33     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
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MeSH Terms
Cardiac Catheterization
Coronary Disease / diagnosis,  drug therapy*
Diltiazem / therapeutic use
Exercise / physiology
Exercise Test
Gallopamil / therapeutic use*
Middle Aged
Myocardium / metabolism
Single-Blind Method
Reg. No./Substance:
39WPC8JHR8/Gallopamil; EE92BBP03H/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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