| Exercise capacity and stroke volume are preserved late after tetralogy repair, despite severe right ventricular dilatation. | |
| | |
MedLine Citation:
|
PMID: 22869677 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To assess if exercise capacity and resting stroke volume are different in tetralogy of Fallot (TOF) repair survivors with indexed RV (right ventricle) end-diastolic volume (RVEDVi) more versus less than 150 ml/m(2), a currently suggested threshold for pulmonary valve replacement (PVR). DESIGN: Cross-sectional study. SETTING: Single-centre adult congenital heart disease unit. PATIENTS: 55 consecutively eligible patients with repaired TOF (age at repair 2.3±1.9 years; age at evaluation 26.2±8.8 years; NYHA Class I or II). INTERVENTIONS: Cardiovascular MRI (1.5T) and cardiopulmonary exercise test. MAIN OUTCOME MEASURES: Biventricular volumes and function; exercise capacity. RESULTS: 20 patients had RVEDVi below, and 35 had RVEDVi above 150 ml/m(2), at time of referral. In the >150 ml/m(2) group, fractional pulmonary regurgitation was higher (41±8 vs 31±8%, p<0.001). Although RV ejection fraction (EF) was lower (47±7 vs 54±6%, p=0.007), indexed RV stroke volume was higher (87±14 vs 64±10 ml/m(2), p<0.001) in the >150 ml/m(2) group. There were no significant differences in LVEF, indexed LV stroke volume or exercise capacity (% predicted peak work: 90±17 vs 89±11% and; % predicted VO(2) peak: 84±17 vs 87±12%). CONCLUSIONS: Exercise capacity and stroke volume are maintained with RVEDVi above compared with below a commonly used cut-off for PVR surgery. Optimal timing for PVR, thus, remains unclear. |
| | |
Authors:
|
Shamus O'Meagher; Phillip A Munoz; Jennifer A Alison; Iven H Young; David J Tanous; David S Celermajer; Rajesh Puranik |
Related Documents
:
|
1443237 - Exhaustive physical exercise causes oxidation of glutathione status in blood: preventio... 22748747 - Addition of tiotropium to formoterol improves inspiratory muscle strength after exercis... 10714277 - Blood glutathione homeostasis as a determinant of resting and exercise-induced oxidativ... 14732477 - Interaction of regular exercise and chronic nitroglycerin treatment on blood pressure a... 22977357 - Anaerobic threshold: its concept and role in endurance sport. 6725087 - Reflex regulation of sweat rate by skin temperature in exercising humans. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-6 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: - ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The University of Sydney, Sydney, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study...
Next Document: Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki ...