| Exercise capacity and prognosis in patients with chronic atrial fibrillation. | |
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MedLine Citation:
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PMID: 7728799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the response of patients with chronic atrial fibrillation (AF) to exercise and to demonstrate if prognosis could be predicted, 200 male patients (64 +/- 1 years) with AF were identified retrospectively who underwent resting echocardiography and symptom-limited treadmill testing. They were classified by underlying disease into three subgroups: hypertension or no underlying disease (LONE; n = 102), ischemic heart disease (IHD; n = 45) and history of congestive heart failure or valvular disease (CHF-VD; n = 53). Maximal exercise capacities for LONE, IHD and CHF-VD were (mean +/- 1 SEM) 8.0 +/- 0.3, 6.4 +/- 0.4 and 6.0 +/- 0.3 metabolic equivalents, respectively (p < 0.01), and resting left ventricular ejection fractions were 61.7 +/- 1.6, 60.1 +/- 2.2 and 49.5 +/- 1.9%, respectively (p < 0.01). Stepwise multiple regression analysis demonstrated that, except for group classification (R2 = 0.13, p < 0.01), no clinical, exercise or morphologic variables could predict exercise capacity. After a mean 39.1-month follow-up (range 1-78), 17 of the 200 had died from cardiovascular causes. The rate of cardiac death using Kaplan-Meier survival analysis was significantly greater in CHF-VD patients (p < 0.01). However, Cox hazard function and Kaplan-Meier survival analysis demonstrated that neither echocardiographic measurements of cardiac size or function at rest, nor exercise or clinical variables were significant predictors of outcome. AF patients with a history of CHF and/or VD demonstrated a reduced exercise tolerance ad a worse prognosis than those without morphologic heart disease or those with IHD.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K Ueshima; J Myers; P M Ribisl; C K Morris; T Kawaguchi; J Liu; V F Froelicher |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology Volume: 86 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1995 |
Date Detail:
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Created Date: 1995-06-01 Completed Date: 1995-06-01 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 108-13 Citation Subset: IM |
Affiliation:
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Cardiology Divisions, Palo Alto, Veterans Affairs Medical Centers, Iwate, CA 94304, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrial Fibrillation / etiology*, mortality, physiopathology*, ultrasonography Chronic Disease Echocardiography Exercise / physiology* Exercise Test Heart Diseases / complications*, ultrasonography Humans Male Middle Aged Prognosis Regression Analysis Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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