Document Detail

Exercise capacity predicts health status in alpha(1)-antitrypsin deficiency.
MedLine Citation:
PMID:  11282769     Owner:  NLM     Status:  MEDLINE    
Resting lung function is only weakly related to health status in chronic obstructive pulmonary disease, reflecting the multifactorial causes of impairment and the heterogeneous nature of the condition. The current study examined whether density mask analysis of high-resolution computed tomography (HRCT) or exercise capacity were better surrogates for health status in a well-defined, homogeneous group of patients with alpha(1)-antitrypsin deficiency (PiZ). Twenty-nine patients with predominantly lower zone emphysema on HRCT were studied. Exercise was assessed by incremental treadmill (V O(2) peak) and shuttle walking tests (ISWT) and health status by the St. George's Respiratory Questionnaire (SGRQ) and SF-36. Although lower zone expiratory HRCT was related to exercise capacity (rho = -0.64 and -0.63 for V O(2) peak and ISWT, respectively, p < 0.001), multiple regression analysis suggested that FEV(1) was a marginally better predictor (rho = -0.64 and -0.65, p < 0.001). HRCT also related significantly to health status (rho = -0.37 for SGRQ activity, p < 0.05), although again FEV(1) showed a stronger relationship (rho = -0.43, p = 0.01). However, exercise capacity was the best predictor of health status with the ISWT accounting for up to 55% of the variability seen in SGRQ total and up to 53% of the SF-36 domain scores (physical functioning). Although both HRCT and lung function relate to health status, exercise capacity is the best predictor of patients disability in these patients with predominantly lower zone emphysema.
L J Dowson; C Newall; P J Guest; S L Hill; R A Stockley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  163     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  936-41     Citation Subset:  AIM; IM    
Lung Investigation Unit, Nuffield House, Queen Elizabeth University Hospital, Birmingham, United Kingdom.
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MeSH Terms
Exercise Test
Exercise Tolerance / physiology*
Health Status*
Middle Aged
Predictive Value of Tests
Prospective Studies
Pulmonary Emphysema / complications,  diagnosis*
Sensitivity and Specificity
Severity of Illness Index
Tomography, X-Ray Computed
alpha 1-Antitrypsin Deficiency / complications,  diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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