Document Detail

Exercise capacity and muscle strength in patients with cirrhosis.
MedLine Citation:
PMID:  22139897     Owner:  NLM     Status:  Publisher    
Exercise capacity and muscular strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state and patients often have muscle wasting. However, the relationships between exercise capacity, strength and outcomes in patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in cirrhotic patients. These have found a significant reduction in exercise capacity and muscle strength in patients with cirrhosis compared to healthy controls. These impairments appear independent of the etiology of cirrhosis, while the data are equivocal in regards to their association with disease severity. Two studies reported a significant and independent association between pre-transplant exercise capacity and post-transplant survival. A further two studies found that exercise training was well-tolerated in patients with cirrhosis, resulting in improvements in exercise capacity in both studies and muscle mass in one. These data are provocative, suggesting that measuring and improving exercise capacity and muscular strength in cirrhotic patients awaiting liver transplantation has the potential to improve outcomes. © 2011 American Association for the Study of Liver Diseases.
Jacqueline C Jones; Jeff S Coombes; Graeme A Macdonald
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-5
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  -     ISSN:  1527-6473     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia.
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