| Exercise capacity, muscle strength and fatigue in sarcoidosis. | |
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MedLine Citation:
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PMID: 21436356 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the case-control study was to investigate the prevalence of exercise intolerance, muscle weakness and fatigue in sarcoidosis patients. Additionally, we evaluated whether fatigue can be explained by exercise capacity, muscle strength or other clinical characteristics (lung function tests, radiographic stages, prednisone usage and inflammatory markers). Sarcoidosis patients referred to the Maastricht University Medical Centre were included (124 patients; mean age: 46.6±10.2 years; 80 men). Patients performed a six-minute walk test (6MWT), handgrip (HGms), elbow flexor (EFms), quadriceps (Qms), hamstrings (Hms) and inspiratory muscle strength tests (Pi,max) and completed the Fatigue Assessment Scale (FAS). The 6MWT was reduced in 45% of the population, while HGms in 15%, EFms in 12%, Qms in 27%, Hms in 18% and Pi,max in 43% of the population. The majority of the patients (81%) reported fatigue (FAS≥22). Patients with reduced peripheral muscle strength of the upper and/or lower extremities were more fatigued and demonstrated impaired lung functions, FFM, Pi,max, 6MWT and quality of life. Fatigue was neither predicted by exercise capacity, nor by muscle strength. Besides fatigue, exercise intolerance and muscle weakness are frequent problems in sarcoidosis. We therefore recommend physical tests in the multidisciplinary management of sarcoidosis patients, even in non-fatigued patients. |
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Authors:
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R G J Marcellis; A F Lenssen; M D P Elfferich; J De Vries; S Kassim; K Foerster; M Drent |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Maastricht University Medical Centre (MUMC). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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