Document Detail

Exercise capacity and mortality in black and white men.
MedLine Citation:
PMID:  18212278     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise capacity is inversely related to mortality risk in healthy individuals and those with cardiovascular diseases. This evidence is based largely on white populations, with little information available for blacks. METHODS AND RESULTS: We assessed the association between exercise capacity and mortality in black (n=6749; age, 58+/-11 years) and white (n=8911; age, 60+/-11 years) male veterans with and without cardiovascular disease who successfully completed a treadmill exercise test at the Veterans Affairs Medical Centers in Washington, DC, and Palo Alto, Calif. Fitness categories were based on peak metabolic equivalents (METs) achieved. Subjects were followed up for all-cause mortality for 7.5+/-5.3 years. Among clinical and exercise test variables, exercise capacity was the strongest predictor of risk for mortality. The adjusted risk was reduced by 13% for every 1-MET increase in exercise capacity (hazard ratio, 0.87; 95% confidence interval, 0.86 to 0.88; P<0.001). Compared with those who achieved <5 METs, the mortality risk was approximately 50% lower for those with an exercise capacity of 7.1 to 10 METs (hazard ratio, 0.51; 95% confidence interval, 0.47 to 0.56; P<0.001) and 70% lower for those achieving >10 METs (hazard ratio, 0.31; 95% confidence interval, 0.26 to 0.36; P<0.001). The findings were similar for those with and without cardiovascular disease and for both races. CONCLUSIONS: Exercise capacity is a strong predictor of all-cause mortality in blacks and whites. The relationship was inverse and graded, with a similar impact on mortality outcomes for both blacks and whites.
Peter Kokkinos; Jonathan Myers; John Peter Kokkinos; Andreas Pittaras; Puneet Narayan; Athanasios Manolis; Pamela Karasik; Michael Greenberg; Vasilios Papademetriou; Steven Singh
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-01-22
Journal Detail:
Title:  Circulation     Volume:  117     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-22     Citation Subset:  AIM; IM    
Veterans Affairs Medical Center/Cardiology Department, 50 Irving St NW, Washington, DC 20422, USA.
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MeSH Terms
African Continental Ancestry Group*
Continental Population Groups / statistics & numerical data*
European Continental Ancestry Group*
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology*
Follow-Up Studies
Middle Aged
Physical Fitness
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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