| Exercise capacity in idiopathic pulmonary fibrosis: The effect of pulmonary hypertension. | |
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MedLine Citation:
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PMID: 21122030 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background and objective: Increased pulmonary arterial pressure (PAP) usually coexists with impaired lung function in IPF. Data on the effect of pulmonary hypertension (PH) on cardiopulmonary responses during exercise in IPF patients is very limited. We sought to investigate the impact of PH on exercise capacity and the correlation between systolic PAP (sPAP) and pulmonary function testing, as well as cardiopulmonary exercise parameters, in patients with IPF and PH. Methods: Eighty-one consecutive patients with IPF, who were evaluated over a 6-year period, were retrospectively studied. Patients underwent pulmonary function testing, Doppler echocardiography and maximal cardiopulmonary exercise testing. PH was defined as sPAP > 35 mm Hg. Results: PH was diagnosed in 57% of the patients. Categorization of patients according to severity of PH indicated a significant reduction in maximum work rate, peak O(2) uptake, anaerobic threshold and peak O(2) pulse in those with sPAP > 50 mm Hg. In IPF patients with PH, estimated sPAP correlated with peak O(2) uptake, anaerobic threshold, peak O(2) pulse and end-tidal CO(2) at anaerobic threshold, while the strongest correlation was between sPAP and ventilatory equivalent for CO(2) at anaerobic threshold (r = 0.611, P < 0.001). There were no differences in pulmonary function or exercise parameters indicative of lung volume reduction, across the patient categories, and none of these parameters correlated with sPAP. Conclusions: PH has a negative impact on exercise capacity in IPF patients. In IPF patients with PH, resting sPAP correlated with exercise parameters indicative of gas exchange and circulatory impairment, but not with defective lung mechanics. |
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Authors:
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Afroditi K Boutou; Georgia G Pitsiou; Ioannis Trigonis; Despina Papakosta; Paschalina K Kontou; Nikolaos Chavouzis; Chrysanthi Nakou; Paraskevi Argyropoulou; Karlman Wasserman; Ioannis Stanopoulos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 16 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 451-8 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology. |
Affiliation:
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Respiratory Failure Unit Pulmonology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California, USA. |
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