| Exercise capacity in heart failure patients: relative importance of heart and skeletal muscle. | |
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MedLine Citation:
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PMID: 8964135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The knee extensor and the whole-body exercise capacities were measured in 11 chronic heart failure (CHF) patients and 11 healthy age- and sex-matched controls, and were related to ejection fraction and to biochemical and histochemical markers of the musculature. The CHF patients had a 39% lower maximal oxygen uptake measured on an ergometer cycle than the healthy controls (1.54 +/- 0.57 vs. 2.51 +/- 0.70 1 min-1, P < 0.001). The low exercise capacity was markedly related to the ejection fraction (r = 0.77, P < 0.001). The maximal strength of m. quadriceps femoris was 15% lower in the CHF patients than in the controls (P < 0.05). The cross-sectional area (CSA) of m. quadriceps femoris explained 55% (r = 0.74, P < 0.001) of the difference in strength between both groups. The endurance capacity of m. quadriceps femoris was 30% lower in CHF patients than in controls, partly as a result of the 25% lower capillary density (P < 0.05) and the 27% lower aerobic enzyme capacity (P < 0.05), as estimated by the citrate synthase activity, in the CHF patients. The citrate synthase activity correlated with the maximal oxygen uptake (r = 0.61, P < 0.05). Moreover, the ejection fraction, together with the CSA of m. quadriceps femoris, explained 75% (r = 0.86%, P < 0.01) of the difference in maximal oxygen uptake between CHF patients and controls. These results demonstrate that CHF patients have both a lower local and a lower whole-body work capacity than healthy controls. This is a function of a smaller leg muscle mass and a lower capillary density and mitochondrial enzyme capacity in the CHF patients; however, a lowered pump capacity of the heart is the factor which limits the exercise capacity the most. |
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Authors:
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G Magnusson; L Kaijser; H Rong; B Isberg; C Sylvén; B Saltin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 16 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-10 Completed Date: 1996-12-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 183-95 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Capillaries / pathology Enzymes / metabolism Exercise Test Female Heart / physiopathology* Heart Failure / pathology, physiopathology* Humans Isometric Contraction Leg Male Middle Aged Muscle Fatigue Muscle, Skeletal / blood supply, pathology, physiopathology* Physical Endurance* |
| Chemical | |
Reg. No./Substance:
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0/Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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