Document Detail

Exercise capacity and blood pressure associations with left ventricular mass in prehypertensive individuals.
MedLine Citation:
PMID:  17088448     Owner:  NLM     Status:  MEDLINE    
Prehypertensive individuals are at increased risk for developing hypertension and cardiovascular disease compared with those with normal blood pressure. Early compromises in left ventricular structure may explain part of the increased risk. We assessed echocardiographic and exercise parameters in prehypertensive individuals (n=790) to determine associations between exercise blood pressure and left ventricular structure. The exercise systolic blood pressure at 5 metabolic equivalents (METs) and the change in blood pressure from rest to 5 METs were the strongest predictors of left ventricular hypertrophy. We identified the systolic blood pressure of 150 mm Hg at the exercise levels of 5 METs as the threshold for left ventricular hypertrophy. There was a 4-fold increase in the likelihood for left ventricular hypertrophy for every 10-mm Hg increment in systolic blood pressure beyond this threshold (OR: 1.15; 95% CI: 1.12 to 1.18). There was also a 42% reduction in the risk for left ventricular hypertrophy for every 1 MET increase in the workload (OR: 0.58; P<0.001). When compared with low-fit, moderate, and high-fit individuals exhibited significantly lower systolic blood pressure at an exercise workload of 5 METs (155+/-14 versus 146+/-10 versus 144+/-10; P<0.05), lower left ventricular mass index (48+/-12 versus 41+/-10 versus 41+/-9; P<0.05), and prevalence of left ventricular hypertrophy (48.3% versus 18.7% versus 21.6%; P<0.001). This suggests that moderate improvements in cardiorespiratory fitness achieved by moderate intensity physical activity can improve hemodynamics and cardiac performance in prehypertensive individuals and reduce the work of the left ventricle, ultimately resulting in lower left ventricular mass.
Peter Kokkinos; Andreas Pittaras; Puneet Narayan; Charles Faselis; Steven Singh; Athanasios Manolis
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Publication Detail:
Type:  Journal Article     Date:  2006-11-06
Journal Detail:
Title:  Hypertension     Volume:  49     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Veterans Affairs Medical Center, Cardiology Division, Washington, DC 20422, USA.
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MeSH Terms
Blood Pressure*
Differential Threshold
Heart Ventricles
Hypertension / etiology*
Hypertrophy, Left Ventricular / etiology,  ultrasonography
Likelihood Functions
Middle Aged
Physical Endurance*
Physical Fitness
Predictive Value of Tests
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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