| Exercise capacity, arrhythmic risk profile, and pulmonary function is not influenced by intracoronary injection of Bone Marrow Stem Cells in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 21392832 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate influence of Bone Marrow Stem Cells (BMSC) intracoronary infusion on exercise capacity, pulmonary function, heart rate recovery and SAECG in patients with AMI of anterior wall, compared to control group - from baseline in the acute phase during 12months follow up. METHODS: Forty five patients were randomized 2:1 to BMSC group (n=31 pts) or to control group (n=14 pts). BMSC were administered into infarct related artery (IRA) at 4-6day after primary PCI. Patients were followed up with cardiopulmonary exercise testing. The QRS duration, QT and QTc interval were measured and signal averaged ECGs (SAECG) were performed to evaluate late potentials. RESULTS: There were no significant differences between both groups neither at peak VO(2) (190.7±7.4 at baseline; 24.2±5.2 at 6months; 22.2±7.4ml/kg/min at 12months vs 18.4±8.2 at baseline; 22.0±7.2 at 6months; 21.8±6.2ml/kg/min at 12months; BMSC vs control group respectively; p=ns), nor VO(2) at anaerobic threshold, nor in VE/VCO(2) slope, RER, and systolic blood pressure at peak exercise at baseline and any time point of follow-up. There were no significant differences between groups concerning HR peak, HRR1 and HRR2 at any time point and also QRS, QT parameters, and SAEKG. There were no significant differences between both groups at any time point (baseline, 6 and 12months) concerning FVC, FEV(1) and FVC/FEV(1) and % of their normal values. CONCLUSIONS: We did not find that BMSC therapy in patients with anterior wall myocardial infarction influences exercise capacity. We did not confirm it's potential proarrhythmogenic influence as assessed with SAECG and standard ECG analysis. |
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Authors:
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Ewa Straburzyńska-Migaj; Małgorzata Popiel; Stefan Grajek; Agnieszka Katarzyńska-Szymańska; Maciej Lesiak; Piotr Bręborowicz; Krzysztof Sawiński; Anna Czyż; Lidia Gil; Maria Kozłowska-Skrzypczak; Mieczysław Komarnicki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-9 |
Journal Detail:
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Title: International journal of cardiology Volume: - ISSN: 1874-1754 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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First Department of Cardiology, Poznań University of Medical Sciences, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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