Document Detail


Exercise capacity after single and twice-daily doses of nicorandil in chronic stable angina pectoris.
MedLine Citation:
PMID:  2525329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a double-blind parallel group study, 46 patients with chronic stable angina were randomized, after a 2-week placebo washout period, to 1 of 3 treatment groups for an additional 2 weeks. Groups 1 and 2 received nicorandil (5 mg, n = 5; 10 mg, n = 10) twice daily, respectively, increasing to 10 and 20 mg (n = 20) twice daily after 1 week of treatment; group 3 continued to receive placebo. A symptom-limited Bruce protocol exercise test was performed before and 2 hours after the initial dose and, after 2 weeks of treatment, 2 and 12 hours after administration. The following parameters were measured: resting, peak exercise and recovery blood pressure and heart rate, exercise duration, time to onset of angina and time to 1 mm of ST-segment depression. After initial dosing, there were significant increases in exercise duration (16%--n = 5, n = 10 vs -2% [placebo]) and time to onset of angina (20%, n = 5; 26%, n = 10 vs 5% [placebo]) (p less than 0.05). Time to onset of 1 mm of ST-segment depression increased in the nicorandil-treated groups compared with that in the placebo group (27%, n = 5; 25%, n = 10 vs 8% [placebo]). Calculated total exercise work increased in both nicorandil groups compared with exercise work in the placebo group (30%, n = 5; 19%, n = 10 vs 3% [placebo]). A decrease in resting systolic blood pressure (12%) in the 10-mg group was the only significant alteration in the hemodynamic parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
T B Meany; P Richardson; A J Camm; J Coltart; M Griffith; M B Maltz; M Signy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  63     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-20     Completed Date:  1989-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66J-70J     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Kings College Hospital, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Angina Pectoris / drug therapy*
Chronic Disease
Clinical Trials as Topic
Double-Blind Method
Humans
Male
Middle Aged
Niacinamide / administration & dosage,  analogs & derivatives*,  therapeutic use
Nicorandil
Physical Exertion*
Placebos
Random Allocation
Vasodilator Agents / administration & dosage*,  therapeutic use
Chemical
Reg. No./Substance:
0/Placebos; 0/Vasodilator Agents; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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