| Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. | |
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MedLine Citation:
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PMID: 20696561 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Elite swimmers have an increased risk of developing asthma, and exposure to chloramine is believed to be an important trigger factor. The aim of the present study was to explore pathophysiological mechanisms behind induced bronchoconstriction in swimmers exposed to chloramine, before and after swim exercise provocation as well as mannitol provocation. Urinary Clara cell protein (CC16) was used as a possible marker for epithelial stress. 101 elite aspiring swim athletes were investigated and urinary samples were collected before and 1 h after completed exercise and mannitol challenge. CC16, 11β-prostaglandin (PG)F(2α) and leukotriene E(4) (LTE(4)) were measured. Urinary levels of CC16 were clearly increased after exercise challenge, while no reaction was seen after mannitol challenge. Similar to CC16, the level of 11β-PGF(2α) was increased after exercise challenge, but not after mannitol challenge, while LTE(4) was reduced after exercise. There was no significant difference in urinary response between those with a negative compared to positive challenge, but a tendency of increased baseline levels of 11β-PGF(2α) and LTE(4) in individuals with a positive mannitol challenge. The uniform increase of CC16 after swim exercise indicates that CC16 is of importance in epithelial stress, and may as such be an important pathogenic factor behind asthma development in swimmers. The changes seen in urinary levels of 11β-PGF(2α) and LTE(4) indicate a pathophysiological role in both mannitol and exercise challenge. |
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Authors:
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Kerstin Romberg; Leif Bjermer; Ellen Tufvesson |
Publication Detail:
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Type: Journal Article Date: 2010-08-08 |
Journal Detail:
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Title: Respiratory medicine Volume: 105 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 31-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Respiratory Medicine and Allergology, Dept. of Clinical Sciences, Lund University, Lund, Sweden; Health Care Centre, Näsets Läkargrupp, Höllviken, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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