Document Detail

Exercise blood pressure is related to insulin resistance in subjects with two hypertensive parents.
MedLine Citation:
PMID:  14763663     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Insulin resistance has been implicated in the pathogenesis of essential hypertension. Elevated blood pressure during physical exercise is a more powerful predictor of future hypertension than resting blood pressure. We have therefore studied the relationship between insulin resistance and blood pressure response to exercise in strongly hypertension-prone subjects. MATERIAL: Twenty-five normotensive subjects aged 18-35 years with bi-parental hypertension, and 26 matched controls with normotensive parents. METHODS: (i) Maximal exercise tolerance test with continuous gas-exchange measurement; (ii) blood pressure at rest, during exercise and 24-h ambulatory; (iii) euglycemic hyperinsulinemic clamp. RESULTS: Diastolic blood pressure during exercise was higher in hypertensionprone subjects as compared to controls, but only in subjects with low insulin sensitivity. Resting and 24-h diastolic blood pressure were higher in hypertension-prone subjects, but independent of insulin sensitivity level. Insulin sensitivity and exercise capacity were similar in the groups. CONCLUSION: Diastolic blood pressure during exercise was higher in hypertension-prone subjects as compared to controls, but only in insulin-resistant subjects. Since elevated blood pressure during physical exertion is a predictor of future hypertension, these findings may suggest that insulin resistance is involved in the pathogenesis of essential hypertension.
Ulrik B Andersen; Michael H Olsen; Harriet Dige-Petersen; Hans Ibsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  12     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2003  
Date Detail:
Created Date:  2004-02-06     Completed Date:  2004-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Denmark.
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MeSH Terms
Blood Pressure / physiology*
Case-Control Studies
Exercise / physiology*
Exercise Test
Family Health*
Hypertension / etiology,  physiopathology*
Insulin Resistance / physiology*
Predictive Value of Tests

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