| Exercise blod flow and microvascualr distensibility in skeletal muscle normalize after heart transplantation. | |
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MedLine Citation:
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PMID: 10515222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the effect of heart transplantation (HTX) on reduced exercise blood flow and microvascular stiffness in patients with congestive heart failure (CHF). Skeletal muscle blood flow (SMBF) during graded maximal supine bicycle exercise and microvascular distensibility (i.e., stiffness) were measured in musculus tibialis anterior by the isotope washout method. Measurements were performed in a cross-sectional study with 31 CHF patients and 28 patients, mean 9 months after HTX, and in a longitudinal study in 12 CHF patients before, 3 months, and 14 months after HTX, and in 31 healthy controls. Maximal SMBF: In the cross-sectional study, maximal SMBF was reduced in severe CHF patients (3.6 +/- 2.5 mL (100 g min)(-1)) and increased after HTX (7.7 +/- 4.8; p < 0.01 versus controls (11 +/- 4.1). Maximal SMBF was reduced in CHF patients (5.8 +/- 4.0) and reversed to normalization 3 months after HTX (10.3 +/- 4.4) in the longitudinal study. Microvascular distensibility: The distensibility was reduced (severe CHF, 12 +/- 8%; moderate CHF, 23 +/- 14%) in the cross-sectional study and increased after HTX towards normalization (38 +/-20%; controls: 44 +/- 17). In the longitudinal study, distensibility in CHF patients (14 +/- 6%) increased gradually to 32 +/- 12% (p < 0.005) at 3 months and normalized 14 months after HTX (46 +/- 17%). HTX gradually reversed the reduced SMBF and microvascular distensibility in CHF patients towards normalization. |
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Authors:
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V B Sørensen; H Wroblewski; S Galatius; S Haunsø; J Kastrup |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical transplantation Volume: 13 ISSN: 0902-0063 ISO Abbreviation: Clin Transplant Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-04 Completed Date: 1999-11-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: DENMARK |
Other Details:
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Languages: eng Pagination: 410-9 Citation Subset: IM |
Affiliation:
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Department of Medicine B, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Blood Pressure Cardiac Output Cross-Sectional Studies Elasticity Exercise Test* Female Heart Failure / physiopathology, surgery Heart Transplantation* Humans Leg Longitudinal Studies Male Microcirculation Middle Aged Muscle, Skeletal / blood supply*, physiopathology Regional Blood Flow Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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