Document Detail

Exercise-based cardiac rehabilitation improves heart rate recovery in elderly patients after acute myocardial infarction.
MedLine Citation:
PMID:  16870634     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart rate recovery (HRR), defined as the fall in HR during the first minute after exercise, is a marker of vagal tone, which is a powerful predictor of mortality in patients with coronary artery disease and in older patients. Whether exercise training (ET) modifies HRR in elderly patients recovering from acute myocardial infarction (AMI) is still unknown. Therefore, this study aims at evaluating the effect of ET on HRR in elderly AMI patients. METHODS: This was a prospective observational study including 268 older patients after AMI (217 men, 51 women), subdivided in two groups: Group A (n = 104), enrolled in an ET program; Group B (n = 164), discharged with generic instructions to continue physical activity. At baseline and at 3-month follow-up, all Group A and 54/164 Group B patients underwent a cardiopulmonary exercise stress test, whereas 110/164 Group B patients underwent an exercise stress test. RESULTS: After completion of the ET program, in Group A we observed an improvement in oxygen consumption at peak exercise (VO2peak; from 14.7 +/- 1.3 to 17.6 +/- 1.9 mL/kg/min, p < .001), in the rate of increase of ventilation per unit of increase of carbon dioxide production (VE/VCO2slope; from 34.2 +/- 3.8 to 30.4 +/- 3.0, p < .001), and in HRR (from 13.5 +/- 3.7 to 18.7 +/- 3.5 beats/min, p < .001). The changes in VO2peak and in VE/VCO2slope after ET were correlated with the improvement of HRR (r = -0.865, p < .01; r = -0.594, p < .01, respectively). No changes in these parameters were observed in Group B patients. CONCLUSIONS: In older AMI patients, ET results in HRR improvement, which was correlated to the improvement in cardiopulmonary parameters. These findings may shed additional light on the possible mechanisms of the beneficial prognostic effects of ET in this patient population.
Francesco Giallauria; Rosa Lucci; Marco Pietrosante; Gaetano Gargiulo; Anna De Lorenzo; Mariantonietta D'Agostino; Giusto Gerundo; Pasquale Abete; Franco Rengo; Carlo Vigorito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  61     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-27     Completed Date:  2006-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  AIM; IM    
Department of Clinical Medicine, Cardiovascular and Immunological Sciences School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
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MeSH Terms
Exercise Test
Exercise Therapy / methods*
Heart Rate / physiology*
Myocardial Infarction / rehabilitation*
Prospective Studies
Treatment Outcome

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