| Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. | |
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MedLine Citation:
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PMID: 21334624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Few studies have investigated if exercise by itself has anti-atherosclerotic effects, without combining interventions with a low-fat diet. We studied the effects of exercise as a stand-alone intervention on preexisting atheromata by measuring not only plaque size but also the levels of plaque-destabilizing matrix-metalloproteinase (MMP) activity in vivo. METHODS AND RESULTS: We used near-infrared fluorescent (NIRF) molecular imaging with an MMP-2/9 activatable NIRF probe to visualize the inflammatory protease activity within preexisting atheromata of 17-week-old ApoE(-/-) mice on: (a) normal chow diet (NCD), (b) Western diet (WD), and (c) WD with treadmill exercise for 10 weeks. We also measured tissue levels of aortic lipid peroxidation (LPO) and plasma levels of glucose/lipid/cytokine profiles. Exercise did not attenuate growth of preexisting atheromatous plaques. However, exercise strongly decreased proteolytic activity in plaques for animals on WD, with levels decreasing almost to NCD levels. Exercise was associated with decreased aortic LPO levels and increased blood adiponectin/leptin levels; however, exercise did not affect WD-consumption/weight-gain or improve blood glucose/lipid profiles. CONCLUSIONS: Exercise training reduced aortic MMP activity in mice with preexisting atheromata, even though they remained on a high fat diet and plaque-growth was not attenuated. |
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Authors:
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Soo-Min Shon; Jong-Ho Park; Matthias Nahrendorf; Dawid Schellingerhout; Jeong-Yeon Kim; Byeong-Teck Kang; Sang-Wuk Jeong; Eo-Jin Kim; Ju Hee Ryu; Kwangmeyung Kim; Ick Chan Kwon; Dong Kun Lee; Myoung Mook Lee; Dong-Eog Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-02 |
Journal Detail:
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Title: Atherosclerosis Volume: 216 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-06 Completed Date: 2011-08-23 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Molecular Imaging and Neurovascular Research Laboratory, Dongguk University Ilsan Hospital, Goyang, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Analysis of Variance Animals Aorta / enzymology*, pathology Aortic Diseases / enzymology, genetics, pathology, therapy* Apolipoproteins E / deficiency, genetics Atherosclerosis / enzymology, genetics, pathology, therapy* Blood Glucose / metabolism Body Weight Cytokines / blood Disease Models, Animal Down-Regulation Exercise Therapy* Immunohistochemistry Infrared Rays Leptin / blood Lipid Peroxidation Lipids / blood Matrix Metalloproteinase 2 / metabolism* Matrix Metalloproteinase 9 / metabolism* Mice Mice, Knockout Microscopy Molecular Imaging / methods Plaque, Atherosclerotic / enzymology, genetics, pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Adipoq protein, mouse; 0/Apolipoproteins E; 0/Blood Glucose; 0/Cytokines; 0/Leptin; 0/Lipids; EC 3.4.24.-/Mmp9 protein, mouse; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.24/Mmp2 protein, mouse; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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