Document Detail


Exercise-associated increases in cardiac biomarkers.
MedLine Citation:
PMID:  18614952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At present, the risk of myocardial damage by endurance exercise is under debate because of reports on exercise-associated increases in cardiac biomarkers troponin and B-type natriuretic peptide (BNP); these markers are typically elevated in patients with acute myocardial infarction and chronic heart failure, respectively. Exercise-associated elevations of cardiac biomarkers can be present in elite and in recreational athletes, especially after prolonged and strenuous endurance exercise bouts (e.g., marathon and ultratriathlon). However, in contrast to cardiac patients, it is still unclear if the exercise-associated appearance or increase in cardiac biomarkers in obviously healthy athletes represents clinically significant cardiac insult or is indeed part of the physiological response to endurance exercise. In addition, elevations in cardiac biomarkers in athletes after exercise may generate difficulties for clinicians in terms of differential diagnosis and may result in inappropriate consequences. Therefore, the aim of this article is to provide an overview of exercise-associated alterations of the cardiac biomarkers troponin T and I, ischemia-modified albumin, BNP, and its cleaved inactive fragment N-terminal pro BNP for the athlete, coach, scientist, and clinician.
Authors:
Jürgen Scharhag; Keith George; Rob Shave; Axel Urhausen; Wilfried Kindermann
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  40     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1408-15     Citation Subset:  IM; S    
Affiliation:
Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken, Germany. j.scharhag@mx.uni-saarland.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers
Echocardiography, Stress
Exercise / physiology*
Heart Injuries / diagnosis*,  pathology
Humans
Male
Natriuretic Peptide, Brain / blood*,  metabolism
Peptide Fragments / blood*,  metabolism
Physical Exertion / physiology
Serum Albumin / analysis,  metabolism
Troponin I / blood*,  metabolism
Troponin T / blood*,  metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Serum Albumin; 0/Troponin I; 0/Troponin T; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical significance of cardiac damage and changes in function after exercise.
Next Document:  Mechanisms underpinning exercise-induced changes in left ventricular function.