Document Detail


Exercise assessment of sinoatrial node function following the Mustard operation.
MedLine Citation:
PMID:  7064768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To screen for sinoatrial node dysfunction following the Mustard procedure for transposition of the great arteries, we studied the chronotropic response to graded maximal treadmill exercise in 29 patients at mean 6.7 years after operation. Although 93% of patients had normal resting heart rate (HR), 83% demonstrated significant depression of maximum HR and/or recovery HR after termination of exercise. These findings were similarly present among a subset of 13 patients with normal exercise tolerance. Resting and exercise-induced HR in 10 patients receiving chronic digoxin therapy were no different than in the 19 patients without medication. Sixteen patients with abnormal chronotropic responses to exercise had intracardiac electrophysiologic evaluation which confirmed sinoatrial node dysfunction in nine. Abnormal HR responses did not correlate with clinical symptoms, cardiac arrhythmias, or postoperative hemodynamics. Maximal exercise testing may be a sensitive noninvasive method to identify sinoatrial node dysfunction in postoperative children.
Authors:
P S Hesslein; H P Gutgesell; P C Gillette; D G McNamara
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  103     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Atrial Flutter / diagnosis
Child
Child, Preschool
Digoxin / therapeutic use
Electrocardiography
Exercise Test
Female
Follow-Up Studies
Heart Block / diagnosis
Heart Catheterization
Heart Rate / drug effects
Humans
Male
Sinoatrial Node / physiology,  physiopathology*
Transposition of Great Vessels / surgery*
Grant Support
ID/Acronym/Agency:
HL-00571/HL/NHLBI NIH HHS; HL-07190/HL/NHLBI NIH HHS; RR-00188/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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