| Exercise as an end-point in pulmonary hypertension trials. | |
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MedLine Citation:
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PMID: 19958394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With recent advances in our understanding of pulmonary hypertension and with ever increasing therapeutic options at our disposal, it remains disappointing that clinical markers of disease progression remain dated. There has long been a search for a more robust clinical correlate than the 6 minute walk test. Resting right heart pressures do not increase linearly with worsening disease, limiting their use as primary endpoints. Some progress has been made however, with 'time to clinical worsening' a composite endpoint of several markers of disease severity. Trials have also been undertaken to evaluate the merits of echocardiographic indices, cardio pulmonary exercise testing and cardiac MRI, with mixed results. With the lack of a sensitive and specific biomarker for pulmonary hypertension, the goal of finding a reproducible endpoint that accurately reflects disease severity and prognosis remains elusive. In this article we discuss relevant endpoints and focus on exercise haemodynamics as a primary endpoint for clinical trials. |
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Authors:
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B McCullagh; R E Girgis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice. Supplement Volume: - ISSN: 1368-504X ISO Abbreviation: Int J Clin Pract Suppl Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-04 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712380 Medline TA: Int J Clin Pract Suppl Country: England |
Other Details:
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Languages: eng Pagination: 4-6 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland. mccullaghbrian@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Disease Progression* Endpoint Determination / instrumentation, methods* Exercise Test / methods* Hemodynamics Humans Hypertension, Pulmonary / diagnosis*, physiopathology* Physical Endurance Predictive Value of Tests Prognosis Reference Values Research Design Walking |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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