Document Detail

Exercise as an augmentation strategy for treatment of major depression.
MedLine Citation:
PMID:  16883145     Owner:  NLM     Status:  MEDLINE    
The use of augmentation strategies among patients with major depression is increasing because rates of complete remission with standard antidepressant monotherapy are quite low. Clinical and neurobiological data suggest that exercise may be a good candidate for use as an augmentation treatment for depression. This pilot study examined the use of exercise to augment antidepressant medication in patients with major depression. Seventeen patients with incomplete remission of depressive symptoms began a 12-week exercise program while continuing their antidepressant medication (unchanged in type or dose). Individual exercise prescriptions were calculated based on an exercise dose consistent with currently recommended public health guidelines. The exercise consisted of both supervised and home-based sessions. The 17-item Hamilton Rating Scale for Depression (HRSD17) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR30) were used to assess symptoms of depression on a weekly basis. Intent-to-treat analyses yielded significant decreases on both the HRSD17 (5.8 points, p < 0.008) and IDS-SR30 (13.9 points, p < 0.002). For patients who completed the study (n = 8), HRSD17 scores decreased by 10.4 points and IDS-SR30 scores decreased by 18.8 points. This study provides preliminary evidence for exercise as an effective augmentation treatment for antidepressant medication. This is a lower-cost augmentation strategy that has numerous health benefits and may further reduce depressive symptoms in partial responders to antidepressant treatment. Practical tips on how practitioners can use exercise to enhance antidepressant treatment are discussed. Longer-term use of exercise is also likely to confer additional health benefits for this population.
Madhukar H Trivedi; Tracy L Greer; Bruce D Grannemann; Heather O Chambliss; Alexander N Jordan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychiatric practice     Volume:  12     ISSN:  1527-4160     ISO Abbreviation:  J Psychiatr Pract     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901141     Medline TA:  J Psychiatr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
University of Texas Southwestern Medical Center at Dallas, Mood Disorders Research Program and Clinic, 6363 Forest Park, Dallas, TX 75235, USA.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Combined Modality Therapy
Cost-Benefit Analysis
Depressive Disorder, Major / diagnosis,  drug therapy*,  economics
Diagnostic and Statistical Manual of Mental Disorders
Energy Metabolism
Motor Activity
Pilot Projects
Time Factors
Grant Support
1R01 MH 067692-01/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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