Document Detail

Exercise as an anabolic intervention in patients with end-stage renal disease.
MedLine Citation:
PMID:  21195920     Owner:  NLM     Status:  MEDLINE    
Muscle wasting and accompanying structural derangements leading to abnormalities in muscle function, exercise performance, and physical activity are common in patients with end-stage renal disease. Therefore, several studies have been performed examining the effects of exercise in this particular patient population. Most of the studies have assessed the effects of cardiopulmonary fitness training, whereas a few have examined the role of resistance (i.e., strength) training. Despite the proven efficacy of resistance exercise as an anabolic intervention in the otherwise healthy elderly population and certain chronic disease states, recent studies in patients on maintenance hemodialysis have not been encouraging in terms of long-term improvements in markers of muscle mass. Preliminary studies indicated that a combination of simultaneous exercise and nutritional supplementation could augment the anabolic effects of exercise, at least in the acute setting. However, a recent randomized clinical trial failed to show further benefits of additional resistance exercise on long-term somatic protein accretion above and beyond nutritional supplementation alone. Further research is necessary to both understand the observed lack of obvious benefits and strategies to improve the exercise regimens in patients with end-stage renal disease.
T Alp Ikizler
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  21     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-05-02     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Dietary Supplements
Kidney Failure, Chronic / complications*,  therapy
Muscular Atrophy / etiology*,  prevention & control*
Randomized Controlled Trials as Topic
Renal Dialysis
Grant Support
K24 DK062849/DK/NIDDK NIH HHS; K24 DK062849-08/DK/NIDDK NIH HHS; R01 DK045604/DK/NIDDK NIH HHS; R01 DK045604-12/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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