Document Detail

Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes.
MedLine Citation:
PMID:  20149706     Owner:  NLM     Status:  MEDLINE    
AIM: This study assessed the impact of regular exercise on inflammatory markers (high-sensitivity C-reactive protein [hsCRP], fibrinogen), and matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), in patients with type 2 diabetes mellitus (T2DM). PATIENTS: Fifty overweight patients with T2DM were randomly assigned to two groups: (A) an exercise group (EXG, n=25), with self-controlled exercise for at least 150 min/week and one additional supervised exercise session/week; and (B) a control group (COG, n=25), with no exercise instructions. All participants were taking oral antidiabetic drugs, and none had diabetic complications. Clinical parameters, exercise capacity (VO(2 peak)), ventilatory threshold (VT), insulin resistance indices (fasting insulin, HOMA-IR, HOMA%S), hsCRP, fibrinogen, MMP-2, MMP-9, TIMP-1 and TIMP-2 were assessed at baseline and after 16 weeks. RESULTS: No significant changes were found in body mass index, waist/hip ratio, insulin-resistance indices, MMP-2 and TIMP-1 throughout the study in either group (P>0.05). Compared with controls, the EXG showed a significant decrease in systolic and mean blood pressure, total and LDL cholesterol, and HbA(1c) (P<0.05). Also, exercise significantly suppressed levels of fibrinogen (P=0.047), hsCRP (P=0.041) and MMP-9 (P=0.028), and the MMP-9-to-TIMP-1 ratio (P=0.038), whereas VO(2 peak) (P=0.011), VT (P=0.008) and plasma TIMP-2 levels (P=0.022) were considerably upregulated in the EXG vs. COG. Standard multiple-regression analyses revealed that MMP-9 changes were independently associated with fibrinogen and HbA(1c) changes, while fibrinogen changes independently predicted TIMP-2 alterations with exercise. CONCLUSION: Mostly self-controlled exercise of moderate intensity ameliorated serum levels of pro- and anti-atherogenic markers in patients with T2DM, with no effects on body weight. These data offer further insight into the cardioprotective mechanisms of exercise in patients with T2DM.
N P E Kadoglou; I S Vrabas; N Sailer; A Kapelouzou; G Fotiadis; G Noussios; P E Karayannacos; N Angelopoulou
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-09
Journal Detail:
Title:  Diabetes & metabolism     Volume:  36     ISSN:  1878-1780     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  144-51     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Masson SAS. All rights reserved.
1st Department of Internal Medicine, Hippokratio General Hospital of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis
Chi-Square Distribution
Diabetes Mellitus, Type 2 / blood*,  enzymology,  therapy
Exercise / physiology*
Fibrinogen / analysis
Matrix Metalloproteinase 9 / blood*
Middle Aged
Regression Analysis
Risk Factors
Tissue Inhibitor of Metalloproteinase-2 / blood*
Reg. No./Substance:
0/Biological Markers; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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