| Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20149706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: This study assessed the impact of regular exercise on inflammatory markers (high-sensitivity C-reactive protein [hsCRP], fibrinogen), and matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), in patients with type 2 diabetes mellitus (T2DM). PATIENTS: Fifty overweight patients with T2DM were randomly assigned to two groups: (A) an exercise group (EXG, n=25), with self-controlled exercise for at least 150 min/week and one additional supervised exercise session/week; and (B) a control group (COG, n=25), with no exercise instructions. All participants were taking oral antidiabetic drugs, and none had diabetic complications. Clinical parameters, exercise capacity (VO(2 peak)), ventilatory threshold (VT), insulin resistance indices (fasting insulin, HOMA-IR, HOMA%S), hsCRP, fibrinogen, MMP-2, MMP-9, TIMP-1 and TIMP-2 were assessed at baseline and after 16 weeks. RESULTS: No significant changes were found in body mass index, waist/hip ratio, insulin-resistance indices, MMP-2 and TIMP-1 throughout the study in either group (P>0.05). Compared with controls, the EXG showed a significant decrease in systolic and mean blood pressure, total and LDL cholesterol, and HbA(1c) (P<0.05). Also, exercise significantly suppressed levels of fibrinogen (P=0.047), hsCRP (P=0.041) and MMP-9 (P=0.028), and the MMP-9-to-TIMP-1 ratio (P=0.038), whereas VO(2 peak) (P=0.011), VT (P=0.008) and plasma TIMP-2 levels (P=0.022) were considerably upregulated in the EXG vs. COG. Standard multiple-regression analyses revealed that MMP-9 changes were independently associated with fibrinogen and HbA(1c) changes, while fibrinogen changes independently predicted TIMP-2 alterations with exercise. CONCLUSION: Mostly self-controlled exercise of moderate intensity ameliorated serum levels of pro- and anti-atherogenic markers in patients with T2DM, with no effects on body weight. These data offer further insight into the cardioprotective mechanisms of exercise in patients with T2DM. |
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Authors:
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N P E Kadoglou; I S Vrabas; N Sailer; A Kapelouzou; G Fotiadis; G Noussios; P E Karayannacos; N Angelopoulou |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-02-09 |
Journal Detail:
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Title: Diabetes & metabolism Volume: 36 ISSN: 1878-1780 ISO Abbreviation: Diabetes Metab. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607599 Medline TA: Diabetes Metab Country: France |
Other Details:
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Languages: eng Pagination: 144-51 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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1st Department of Internal Medicine, Hippokratio General Hospital of Thessaloniki, Thessaloniki, Greece. nikoskad@yahoo.com |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00306176 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood C-Reactive Protein / analysis Chi-Square Distribution Diabetes Mellitus, Type 2 / blood*, enzymology, therapy Exercise / physiology* Female Fibrinogen / analysis Humans Male Matrix Metalloproteinase 9 / blood* Middle Aged Regression Analysis Risk Factors Tissue Inhibitor of Metalloproteinase-2 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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