Document Detail

Exercise, alveolar macrophage function, and susceptibility to respiratory infection.
MedLine Citation:
PMID:  9375306     Owner:  NLM     Status:  MEDLINE    
The effects of exercise on susceptibility to respiratory infection were determined by using a murine model of intranasal challenge with herpes simplex type 1 virus (HSV-1). Two doses of treadmill exercise were assessed: moderate short-term (30 min) exercise and prolonged strenuous exercise to voluntary fatigue (2.5-3.5 h). Morbidity and mortality among exercised and control mice were compared after intranasal challenge with HSV-1. We also assessed the ability of alveolar macrophages to restrict HSV-1 viral replication (intrinsic resistance) among exercise and control groups of mice at several time points postexercise. Exercise to fatigue followed by exposure to viral infection resulted in greater morbidity and mortality than either no exercise or short-term moderate exercise. In addition, antiviral resistance of macrophages obtained from the lungs of both exercised groups was suppressed, albeit for a longer duration in the fatigued group. These data are particularly important in that they identify an exercise-induced decrease in antiviral resistance of a specific component of the immune system within the lungs, in conjunction with increased susceptibility to respiratory infection in vivo. The specific mechanism of decreased antiviral resistance of alveolar macrophages and its role in respiratory infection after exercise remains to be determined.
J M Davis; M L Kohut; L H Colbert; D A Jackson; A Ghaffar; E P Mayer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-30     Completed Date:  1997-12-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1461-6     Citation Subset:  IM    
Department of Exercise Science, School of Public Health, University of South Carolina, Columbia 29208, USA.
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MeSH Terms
Administration, Intranasal
Herpes Simplex / mortality,  physiopathology*,  virology
Herpesvirus 1, Human*
Macrophages, Alveolar / physiology*,  virology
Physical Exertion / physiology*
Respiratory Tract Infections / mortality,  physiopathology*,  virology
Time Factors
Virus Replication / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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