| Exercise above the ischemic threshold and serum markers of myocardial injury. | |
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MedLine Citation:
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PMID: 19812806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Current guidelines for exercise training in coronary patients state that in the presence of exercise-induced ischemia, the heart rate during exercise should be at least 10 beats/min below the heart rate associated with an ST segment depression of 1 mm or greater. For patients with a relatively low ischemic threshold, this recommendation does not allow for a sufficient training stimulus. OBJECTIVE: To document the effects of a single session of exercise above the ischemic threshold on biochemical markers of myocardial injury in stable coronary patients with exercise-induced ischemia. Because creatine kinase (CK) and its MB isoenzyme (CK-MB) can both increase after exercise because of skeletal muscle injury, troponin T was also measured. METHODS: Twenty-one patients with documented coronary artery disease underwent two 20 min exercise sessions. The intensity of the first exercise training session was fixed at a heart rate below the ischemic threshold (ie, approximately 10 beats/min lower than the heart rate associated with the appearance of an ST segment depression of 1 mm or greater). The intensity of the second exercise session was fixed at a heart rate above the ischemic threshold. RESULTS: Blood test measurements at baseline, 6 h after and 24 h after the exercise sessions did not show any increase in total CK, CK-MB or troponin. The value of all measurements remained well below the lower limits associated with myocardial damage. CONCLUSION: A 20 min period of exercise above the ischemic threshold did not result in myocardial necrosis. |
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Authors:
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Martin Juneau; Nathalie Roy; Anil Nigam; Jean Claude Tardif; Lucie Larivée |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 25 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-08 Completed Date: 2009-10-27 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: e338-41 Citation Subset: IM |
Affiliation:
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Department of Medicine, Montreal Heart Institute, Montreal, Canada. martine.juneau@icm-mhi.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Coronary Artery Disease / blood, physiopathology, rehabilitation* Creatine Kinase / blood* Creatine Kinase, MB Form / blood* Electrocardiography Exercise Test / methods* Exercise Therapy / methods* Exercise Tolerance / physiology* Follow-Up Studies Heart Rate / physiology Humans Male Middle Aged Prognosis Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin T; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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