Document Detail

Exercise above the ischemic threshold and serum markers of myocardial injury.
MedLine Citation:
PMID:  19812806     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Current guidelines for exercise training in coronary patients state that in the presence of exercise-induced ischemia, the heart rate during exercise should be at least 10 beats/min below the heart rate associated with an ST segment depression of 1 mm or greater. For patients with a relatively low ischemic threshold, this recommendation does not allow for a sufficient training stimulus.
OBJECTIVE: To document the effects of a single session of exercise above the ischemic threshold on biochemical markers of myocardial injury in stable coronary patients with exercise-induced ischemia. Because creatine kinase (CK) and its MB isoenzyme (CK-MB) can both increase after exercise because of skeletal muscle injury, troponin T was also measured.
METHODS: Twenty-one patients with documented coronary artery disease underwent two 20 min exercise sessions. The intensity of the first exercise training session was fixed at a heart rate below the ischemic threshold (ie, approximately 10 beats/min lower than the heart rate associated with the appearance of an ST segment depression of 1 mm or greater). The intensity of the second exercise session was fixed at a heart rate above the ischemic threshold.
RESULTS: Blood test measurements at baseline, 6 h after and 24 h after the exercise sessions did not show any increase in total CK, CK-MB or troponin. The value of all measurements remained well below the lower limits associated with myocardial damage.
CONCLUSION: A 20 min period of exercise above the ischemic threshold did not result in myocardial necrosis.
Martin Juneau; Nathalie Roy; Anil Nigam; Jean Claude Tardif; Lucie Larivée
Related Documents :
2293816 - "recovery only" st-segment depression and the predictive accuracy of the exercise test.
11230836 - Effects of quinapril on clinical outcome after coronary artery bypass grafting (the quo...
16675416 - Can we identify sources of fine particles responsible for exercise-induced ischemia on ...
6613866 - Directional st-segment deviation in graded exercise tests correlated with motion of the...
1423946 - Active skeletal muscle mass and cardiopulmonary reserve. failure to attain peak aerobic...
3017156 - Exercise-induced "asthma" as a presentation of bronchial carcinoid.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  25     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2009-10-27     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e338-41     Citation Subset:  IM    
Department of Medicine, Montreal Heart Institute, Montreal, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Coronary Artery Disease / blood,  physiopathology,  rehabilitation*
Creatine Kinase / blood*
Creatine Kinase, MB Form / blood*
Exercise Test / methods*
Exercise Therapy / methods*
Exercise Tolerance / physiology*
Follow-Up Studies
Heart Rate / physiology
Middle Aged
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; EC Kinase; EC Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence and characteristics of home Internet access in patients with cardiovascular disease from ...
Next Document:  Outcomes in heart failure patients referred for consideration of implantable cardioverter defibrilla...