Document Detail

Exercise Training in Patients with Heart Failure and Preserved Ejection Fraction: A Meta-analysis of Randomized Control Trials.
MedLine Citation:
PMID:  25399909     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Heart failure with preserved ejection fraction (HFPEF) is common and characterized by exercise intolerance and lack of proven effective therapies. Exercise training has been shown to be effective in improving cardiorespiratory fitness (CRF) in patients with systolic heart failure. In this meta-analysis, we aim to evaluate the effects of exercise training on CRF, quality of life and diastolic function in patients with HFPEF.
METHODS AND RESULTS: -Randomized controlled clinical trials that evaluated the efficacy of exercise training in patients with HFPEF were included in this meta-analysis. Primary outcome of the study was change in CRF (measured as change in peak oxygen uptake). Impact of exercise training on quality of life (estimated using Minnesota living with heart failure score), left ventricular systolic and diastolic function was also assessed. The study included 276 patients that were enrolled in 6 randomized controlled trials. In the pooled data analysis, HFPEF patients undergoing exercise training had significantly improved CRF (L/min) (Mean difference: 2.72; 95% CI: 1.79 to 3.65) and quality of life (Mean difference: -3.97; 95% CI: -7.21 to -0.72) as compared with the control group. However, no significant change was observed in the systolic function [Ejection Fraction - Weighted Mean difference (WMD): 1.26; 95% CI: -0.13% to 2.66%] or diastolic function [E/A - WMD: 0.08; 95% CI:-0.01 to 0.16] with exercise training in HFPEF patients.
CONCLUSIONS: -Exercise training in patients with HFPEF is associated with an improvement in CRF and quality of life without significant changes in left ventricular systolic or diastolic function.
Ambarish Pandey; Akhil Parashar; Dharam Kumbhani; Sunil Agarwal; Jalaj Garg; Dalane Kitzman; Benjamin Levine; Mark Drazner; Jarett D Berry
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-16
Journal Detail:
Title:  Circulation. Heart failure     Volume:  -     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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