Document Detail

Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial.
MedLine Citation:
PMID:  20852060     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart failure (HF) with preserved left ventricular ejection fraction (HFPEF) is the most common form of HF in the older population. Exercise intolerance is the primary chronic symptom in patients with HFPEF and is a strong determinant of their reduced quality of life (QOL). Exercise training (ET) improves exercise intolerance and QOL in patients with HF with reduced ejection fraction (EF). However, the effect of ET in HFPEF has not been examined in a randomized controlled trial.
METHODS AND RESULTS: This 16-week investigation was a randomized, attention-controlled, single-blind study of medically supervised ET (3 days per week) on exercise intolerance and QOL in 53 elderly patients (mean age, 70±6 years; range, 60 to 82 years; women, 46) with isolated HFPEF (EF ≥50% and no significant coronary, valvular, or pulmonary disease). Attention controls received biweekly follow-up telephone calls. Forty-six patients completed the study (24 ET, 22 controls). Attendance at exercise sessions in the ET group was excellent (88%; range, 64% to 100%). There were no trial-related adverse events. The primary outcome of peak exercise oxygen uptake increased significantly in the ET group compared to the control group (13.8±2.5 to 16.1±2.6 mL/kg per minute [change, 2.3±2.2 mL/kg per minute] versus 12.8±2.6 to 12.5±3.4 mL/kg per minute [change, -0.3±2.1 mL/kg per minute]; P=0.0002). There were significant improvements in peak power output, exercise time, 6-minute walk distance, and ventilatory anaerobic threshold (all P<0.002). There was improvement in the physical QOL score (P=0.03) but not in the total score (P=0.11).
CONCLUSIONS: ET improves peak and submaximal exercise capacity in older patients with HFPEF.
Dalane W Kitzman; Peter H Brubaker; Timothy M Morgan; Kathryn P Stewart; William C Little
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-09-17
Journal Detail:
Title:  Circulation. Heart failure     Volume:  3     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-17     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659-67     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anaerobic Threshold
Exercise Therapy*
Exercise Tolerance
Heart Failure / physiopathology*,  rehabilitation*
Middle Aged
Oxygen Consumption
Physical Education and Training*
Quality of Life
Single-Blind Method
Stroke Volume*
Grant Support
NIH M01RR07122/RR/NCRR NIH HHS; P30 AG021332/AG/NIA NIH HHS; P30AG21332/AG/NIA NIH HHS; R01 AG012257/AG/NIA NIH HHS; R01 AG018915/AG/NIA NIH HHS; R01AG12257/AG/NIA NIH HHS; R37 AG018915/AG/NIA NIH HHS; R37 AG018915-09S1/AG/NIA NIH HHS; R37 AG018915-10/AG/NIA NIH HHS; R37AG18915/AG/NIA NIH HHS

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