Document Detail

Exercise training in haemodialysis patients: a systematic review and meta-analysis.
MedLine Citation:
PMID:  21557787     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We quantified baseline and observed change in peak VO(2) , quality of life, cardiac function, strength and energy intake following exercise training in haemodialysis patients and optimal exercise delivery for producing greatest adherence, safety and patient improvements.
METHODS: A systematic literature search was completed in August 2010 to identify randomized, controlled trials of exercise training studies in haemodialysis patients. A subsequent meta-analysis was conducted and the search repeated in December 2010.
RESULTS: Fifteen studies, yielding 565 patients were included. Baseline, peak VO(2) values were 70% of age-predicted values, exercise intervention patients improved post-training peak VO(2) to 88% predicted. Exercise training produced mean 26 ± 12% improvements in eight studies that reported peak VO(2) , mean difference 5.22 mL O(2) /kg per min (95% confidence interval 3.86, 6.59, P < 0.00001). Equivocal results for change in short-form 36 health questionnaire scores were reported post-training. Heart rate variability was improved after exercise training of normal to normal interval, mean difference 1634 milliseconds (95% confidence interval 8.3, 24.3, P < 0.0001). Significant improvements in lean body mass, quadriceps muscle area, knee extension, hip abduction and flexion strength were also reported (all P < 0.0001). Exercise training appears safe, with no deaths directly associated with exercise in 28 400 patient-hours and no differences in withdrawal rates between exercise and control participants, P = 0.98. Exercise training for 6 months or more conveyed larger improvements in peak VO(2) than shorter programmes. Data indicate about 25% of patients were excluded from exercise training studies for medical reasons.
CONCLUSION: Exercise training is safe and imparts large improvements in peak VO(2) , and heart rate variability.
Neil Smart; Michael Steele
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  16     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2012-01-11     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  626-32     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.
Department of Exercise Science, University of New England, Armidale, Queensland, Australia.
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MeSH Terms
Energy Intake
Exercise Therapy* / adverse effects
Exercise Tolerance*
Heart Rate
Kidney Diseases / physiopathology,  therapy*
Muscle Strength
Oxygen Consumption
Quality of Life
Renal Dialysis* / adverse effects
Time Factors
Treatment Outcome
Ventricular Function, Left
Comment In:
J Physiother. 2012;58(2):130   [PMID:  22613246 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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