Document Detail


Exercise training reduces PGE2 levels and induces recovery from steatosis in tumor-bearing rats.
MedLine Citation:
PMID:  21064006     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The effects of endurance training on PGE (2) levels and upon the maximal activity of hepatic carnitine palmitoyltransferase (CPT) system were studied in rats bearing the Walker 256 carciosarcoma. Animals were randomly assigned to a sedentary control (SC), sedentary tumor-bearing (ST), exercised control (EC), and as an exercised tumor-bearing (ET) group. Trained rats ran on a treadmill (60% VO (2) max) for 60 min/day, 5 days/week, for 8 weeks. We examined the mRNA expression (RT-PCR) and maximal activity (radioassay) of the carnitine palmitoyltransferase system enzymes (CPT I and CPT II), as well as the gene expression of fatty-acid-binding protein (L-FABP) in the liver. PGE (2) content was measured in the serum, in tumor cells, and in the liver (ELISA). CPT I and CPT II maximal activity were decreased (p<0.01) in ST when compared with SC. In contrast, serum PGE (2) was increased (p<0.05) in cachectic animals as compared with SC. In the liver, PGE (2) content was also increased (p<0.05) when compared with SC. Endurance training restored maximal CPT I and CPT II activity in the tumor-bearing animals (p<0.0001). Exercise training induced PGE (2) levels to return to control values in the liver of tumor-bearing training rats (p<0.05) and decreased the eicosanoid content in the tumor (p<0.01). In conclusion, endurance training was capable of reestablishing liver carnitine palmitoyltransferase (CPT) system activity associated with decreased PGE (2) levels in cachectic tumor-bearing animals, preventing steatosis.
Authors:
F S Lira; A Yamashita; L C Carnevali; D C Gonçalves; W P Lima; J C Rosa; E C Caperuto; L F C Rosa; M Seelaender
Related Documents :
12856186 - Calcineurin is not involved in some mitochondrial enzyme adaptations to endurance exerc...
19297546 - Exercise training inducibility of mnsod protein expression and activity is retained whi...
2137986 - Enhanced calcium uptake of cardiac sarcoplasmic reticulum in exercise-trained old rats.
20726846 - The effects of early exercise on brain damage and recovery after focal cerebral infarct...
1253786 - Pulmonary o2 diffusing capacity at exercise by a modified rebreathing method.
12066566 - Scintigraphic results in asymptomatic myocardial infarction patients with exercise-indu...
Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  42     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  944-9     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus carriage rates in...
Next Document:  Perspective of chemical fingerprinting of Chinese herbs.