| Exercise training improves vasoreactivity in the knee artery. | |
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MedLine Citation:
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PMID: 22095322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical activity has been shown to enhance endothelial function of central and peripheral vascular beds. The primary purpose of the present study was to test the hypothesis that a short-term exercise training program would result in enhanced endothelium-dependent vasorelaxation of a major artery supplying blood flow to the knee joint, the middle genicular artery. Female Yucatan miniature swine were randomly assigned into exercise trained (n=7) or sedentary (n=7) groups. Exercise trained pigs underwent a daily exercise training program on treadmills for 7 days. In vitro assessment of vasorelaxation was determined in a dose response manner by administrating increasing doses of 3 different dilators; adenosine diphosphate, bradykinin, and sodium nitroprusside. The role of nitric oxide synthase and cyclooxygenase pathways in vasomotor responses was evaluated with specific inhibitors using nitro-L-arginine methyl ester and indomethacin incubation, respectively. The results of this investigation indicate that adenosine and bradykinin-induced endothelium-dependent vasorelaxation were significantly enhanced in middle genicular artery from exercise trained pigs (p<0.05). Endothelium-independent vasorelaxation was not altered with exercise training as determined by the response to sodium nitroprusside. The findings of the present investigation indicate that short-term exercise training enhances endothelial function of middle genicular artery through adaptations in the nitric oxide synthase and by non-nitric oxide synthase, non-cyclooxygenase pathways. |
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Authors:
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L E Delaney; A A Arce-Esquivel; K Kuroki; M H Laughlin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-17 |
Journal Detail:
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Title: International journal of sports medicine Volume: 33 ISSN: 1439-3964 ISO Abbreviation: Int J Sports Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-09 Completed Date: 2012-06-01 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 114-22 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Department of Biomedical Sciences, University of Missouri, Columbia 65203, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Animals Bradykinin / pharmacology Endothelium, Vascular / metabolism Female Knee Joint / blood supply* Nitric Oxide Synthase / metabolism Nitroprusside / pharmacology Physical Conditioning, Animal / physiology* Random Allocation Swine Swine, Miniature Vasodilation / drug effects, physiology* Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-36088/HL/NHLBI NIH HHS; P01 HL052490-15/HL/NHLBI NIH HHS; P01-HL-52490/HL/NHLBI NIH HHS; R01 HL036088/HL/NHLBI NIH HHS; R01 HL036088-24/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 58-64-0/Adenosine Diphosphate; 58-82-2/Bradykinin; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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