Document Detail


Exercise training improves vasoreactivity in the knee artery.
MedLine Citation:
PMID:  22095322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical activity has been shown to enhance endothelial function of central and peripheral vascular beds. The primary purpose of the present study was to test the hypothesis that a short-term exercise training program would result in enhanced endothelium-dependent vasorelaxation of a major artery supplying blood flow to the knee joint, the middle genicular artery. Female Yucatan miniature swine were randomly assigned into exercise trained (n=7) or sedentary (n=7) groups. Exercise trained pigs underwent a daily exercise training program on treadmills for 7 days. In vitro assessment of vasorelaxation was determined in a dose response manner by administrating increasing doses of 3 different dilators; adenosine diphosphate, bradykinin, and sodium nitroprusside. The role of nitric oxide synthase and cyclooxygenase pathways in vasomotor responses was evaluated with specific inhibitors using nitro-L-arginine methyl ester and indomethacin incubation, respectively. The results of this investigation indicate that adenosine and bradykinin-induced endothelium-dependent vasorelaxation were significantly enhanced in middle genicular artery from exercise trained pigs (p<0.05). Endothelium-independent vasorelaxation was not altered with exercise training as determined by the response to sodium nitroprusside. The findings of the present investigation indicate that short-term exercise training enhances endothelial function of middle genicular artery through adaptations in the nitric oxide synthase and by non-nitric oxide synthase, non-cyclooxygenase pathways.
Authors:
L E Delaney; A A Arce-Esquivel; K Kuroki; M H Laughlin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-17
Journal Detail:
Title:  International journal of sports medicine     Volume:  33     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-09     Completed Date:  2012-06-01     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  114-22     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Animals
Bradykinin / pharmacology
Endothelium, Vascular / metabolism
Female
Knee Joint / blood supply*
Nitric Oxide Synthase / metabolism
Nitroprusside / pharmacology
Physical Conditioning, Animal / physiology*
Random Allocation
Swine
Swine, Miniature
Vasodilation / drug effects,  physiology*
Vasodilator Agents / pharmacology
Grant Support
ID/Acronym/Agency:
HL-36088/HL/NHLBI NIH HHS; P01 HL052490/HL/NHLBI NIH HHS; P01 HL052490-15/HL/NHLBI NIH HHS; P01-HL-52490/HL/NHLBI NIH HHS; R01 HL036088/HL/NHLBI NIH HHS; R01 HL036088-24/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 169D1260KM/Nitroprusside; 61D2G4IYVH/Adenosine Diphosphate; EC 1.14.13.39/Nitric Oxide Synthase; S8TIM42R2W/Bradykinin
Comments/Corrections

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