| Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial. | |
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MedLine Citation:
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PMID: 22536936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduced heart rate variability (HRV) in older patients with heart failure (HF) is common and indicates poor prognosis. Exercise training (ET) has been shown to improve HRV in younger patients with HF. However, the effect of ET on HRV in older patients with HF is not known. Sixty-six participants (36% men), aged 69±5 years, with HF and both preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF), were randomly assigned to 16 weeks of supervised ET (ET group) vs attention-control (AC group). Two HRV parameters (the standard deviation of all normal RR intervals [SDNN] and the root mean square of successive differences in normal RR intervals [RMSSD]) were measured at baseline and after completion of the study. When compared with the AC group, the ET group had a significantly greater increase in both SDNN (15.46±5.02 ms in ET vs 2.37±2.13 ms in AC, P=.016) and RMSSD (17.53±7.83 ms in ET vs 1.69±2.63 ms in AC, P=.003). This increase was seen in both sexes and HF categories. ET improved HRV in older patients with both HFREF and HFPEF. |
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Authors:
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Khalil Murad; Peter H Brubaker; David M Fitzgerald; Timothy M Morgan; David C Goff; Elsayed Z Soliman; Joel D Eggebeen; Dalane W Kitzman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-26 |
Journal Detail:
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Title: Congestive heart failure (Greenwich, Conn.) Volume: 18 ISSN: 1751-7133 ISO Abbreviation: Congest Heart Fail Publication Date: 2012 Jul-Aug |
Date Detail:
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Created Date: 2012-07-19 Completed Date: 2012-12-05 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9714174 Medline TA: Congest Heart Fail Country: United States |
Other Details:
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Languages: eng Pagination: 192-7 Citation Subset: IM |
Copyright Information:
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© 2012 Wiley Periodicals, Inc. |
Affiliation:
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Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. kmurad@wakehealth.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aging Analysis of Variance Exercise Therapy* Exercise Tolerance Female Heart Failure / pathology, therapy* Heart Rate / physiology* Humans Male Single-Blind Method |
| Grant Support | |
ID/Acronym/Agency:
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5T32HL087730-02/HL/NHLBI NIH HHS; MO1RR07122/RR/NCRR NIH HHS; P30AG21332/AG/NIA NIH HHS; R01 AG012257-06/AG/NIA NIH HHS; R01AG12257/AG/NIA NIH HHS; R37 AG018915/AG/NIA NIH HHS; R37 AG018915-05/AG/NIA NIH HHS; R37AG18915/AG/NIA NIH HHS; T32 HL087730-02/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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