Document Detail

Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial.
MedLine Citation:
PMID:  22536936     Owner:  NLM     Status:  MEDLINE    
Reduced heart rate variability (HRV) in older patients with heart failure (HF) is common and indicates poor prognosis. Exercise training (ET) has been shown to improve HRV in younger patients with HF. However, the effect of ET on HRV in older patients with HF is not known. Sixty-six participants (36% men), aged 69±5 years, with HF and both preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF), were randomly assigned to 16 weeks of supervised ET (ET group) vs attention-control (AC group). Two HRV parameters (the standard deviation of all normal RR intervals [SDNN] and the root mean square of successive differences in normal RR intervals [RMSSD]) were measured at baseline and after completion of the study. When compared with the AC group, the ET group had a significantly greater increase in both SDNN (15.46±5.02 ms in ET vs 2.37±2.13 ms in AC, P=.016) and RMSSD (17.53±7.83 ms in ET vs 1.69±2.63 ms in AC, P=.003). This increase was seen in both sexes and HF categories. ET improved HRV in older patients with both HFREF and HFPEF.
Khalil Murad; Peter H Brubaker; David M Fitzgerald; Timothy M Morgan; David C Goff; Elsayed Z Soliman; Joel D Eggebeen; Dalane W Kitzman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-26
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  18     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-19     Completed Date:  2012-12-05     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Age Factors
Analysis of Variance
Exercise Therapy*
Exercise Tolerance
Heart Failure / pathology,  therapy*
Heart Rate / physiology*
Single-Blind Method
Grant Support
5T32HL087730-02/HL/NHLBI NIH HHS; MO1RR07122/RR/NCRR NIH HHS; P30AG21332/AG/NIA NIH HHS; R01 AG012257/AG/NIA NIH HHS; R01 AG012257-06/AG/NIA NIH HHS; R01AG12257/AG/NIA NIH HHS; R37 AG018915/AG/NIA NIH HHS; R37 AG018915-05/AG/NIA NIH HHS; R37AG18915/AG/NIA NIH HHS; T32 HL087730/HL/NHLBI NIH HHS; T32 HL087730-02/HL/NHLBI NIH HHS

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