Document Detail

Exercise Training Improves HR responses and VO2peak in Predialysis Kidney Patients.
MedLine Citation:
PMID:  22811032     Owner:  NLM     Status:  Publisher    
PURPOSE: The current pilot and feasibility study was designed to examine the effect of 48 weeks of moderate intensity exercise training and dietary modification on kidney function and vascular parameters in chronic kidney disease (CKD) patients. METHODS: Twenty-one stage 2-4 CKD patients (age 18-70 years) were randomly assigned to either the training group (TG, n=10) or the usual care group (UC, n= 11) for 48 weeks. The TG received 48 weeks of personal training (3 days/week for up to 55 minutes per session at 50-60% V˙O2peak) and dietary counseling while individuals in the UC received standard of care and were instructed not to start a structured exercise program while in the study. V˙O2peak, estimated glomerular filtration rate (eGFR), resting and ambulatory heart rate (HR), plasma lipids (total cholesterol, LDL-c, HDL-c, triglycerides), and inflammatory markers (hsCRP, IL6) were assessed at baseline and weeks 24 and 48. An independent groups t-test was used to compare GFR slopes between groups while all other data were analyzed with ANCOVA using the baseline value as the covariate. RESULTS: There were no statistically significant differences in any of the parameters at baseline. The 48-weeks intervention led to a significant increase in V˙O2peak, reductions in both resting and ambulatory HRs and increases in LDLc and in TG, but it had no effect on the rate of change of eGFR over time. CONCLUSIONS: A 48 week exercise training program, primarily focused on aerobic exercise, increases V˙O2peak and favorably alters autonomic function as evidenced by reductions in heart rates in stages 2-4 CKD patients. The exercise intervention had no effect on kidney function as assessed by eGFR.
Samuel Headley; Michael Germain; Charles Milch; Linda Pescatello; Mary Ann Coughlin; Bradley C Nindl; Allen Cornelius; Sheila Sullivan; Sara Gregory; Richard Wood
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Springfield College, Springfield, MA, 2Western New England Renal & Transplant Associates, Springfield, MA 3University of Connecticut, Storrs, CT4 U.S. Army Research Institute of Environmental Medicine, Natick, MA 5University of The Rockies, Colorado Springs, CO 6 Baystate Medical Center, Springfield, MA.
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