Document Detail


Exercise training improved insulin sensitivity and ovarian morphology in rats with polycystic ovary syndrome.
MedLine Citation:
PMID:  19693748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperandrogenism and hyperinsulinemia are major clinical features in women with polycystic ovary syndrome (PCOS). We hypothesized that serum insulin levels reduced by exercise could relieve hyperandrogenism and ameliorate polycystic ovarian morphology. Wistar female rats with 21-day-old were randomly divided into three groups: PCOS exercise (P-Ex), PCOS sedentary (P-Sed), and control sedentary (C-Sed). The rats with PCOS were induced by injection with testosterone propionate continuously. The exercise program was to swim with 120 min/d for two weeks. Fasting blood glucose (FBG) and insulin (FINS), estrogen (E (2)), progesterone (P), and testosterone (T) in serum were determined by RIA, and ovarian morphology was evaluated by Image-Pro Plus 6.0. The levels of FINS, E (2), and T in serum were significantly lower in P-Ex than in P-Sed. The ratios of FBG/FINS in P-Ex significantly increased in comparison with P-Sed. The levels of serum sex hormones in P-Ex were similar to C-Sed. There were no differences in blood glucose and serum progesterone among three groups. Ovarian morphology showed that the numbers of preantral follicles and atretic follicles significantly decreased, and the numbers of antral follicles and corpora lutea significantly increased in P-Ex compared with P-Sed. The changes of ovarian morphology in P-Ex were similar to C-Sed. These results demonstrated that short-term exercise training can improve insulin sensibility, decrease serum androgen levels, and recover normal ovarian morphology. The exercise training is the basic therapeutic means for PCOS.
Authors:
S Qiu; C Wu; F Lin; L Chen; Z Huang; Z Jiang
Related Documents :
20674948 - Exercise training in ovariectomized rats stimulates estrogenic-like effects on expressi...
18586228 - Beneficial effects of treadmill training in a cerebral palsy-like rodent model: walking...
8904558 - Exercise training improves lusitropy by isoproterenol in papillary muscles from aged rats.
16441918 - L-arginine attenuates xanthine oxidase and myeloperoxidase activities in hearts of rats...
7649148 - Change in the peripheral co2 chemoreflex from rest to exercise.
15778898 - Peak oxygen uptake during running and arm cranking normalized to total and regional ske...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme     Volume:  41     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  880-5     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart. New York.
Affiliation:
Department of Rehabilitation Medicine, Nanjing Medical University, 210029 Nanjing, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Female
Gonadal Steroid Hormones / blood
Insulin / blood,  metabolism*
Organ Size
Ovary / pathology*
Physical Conditioning, Animal*
Polycystic Ovary Syndrome / blood,  pathology*
Rats
Rats, Wistar
Vaginal Smears
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Congenital adrenal hyperplasia: a critical appraisal of the evolution of feminizing genitoplasty and...
Next Document:  Where has the tumor gone? The characteristics of cases of negative pathologic diagnosis after endosc...