| Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults. | |
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MedLine Citation:
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PMID: 19844089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The aim of this study was to assess the combined effects of exercise and dietary glycemic load on insulin resistance in older obese adults. METHODS: Eleven men and women (62 +/- 2 years; 97.6 +/- 4.8 kg; body mass index 33.2 +/- 2.0) participated in a 12-week supervised exercise program, 5 days/week, for about 1 h/day, at 80-85% of maximum heart rate. Dietary glycemic load was calculated from dietary intake records. Insulin resistance was determined using the euglycemic (5.0 mM) hyperinsulinemic (40 mU/m(2)/min) clamp. RESULTS: The intervention improved insulin sensitivity (2.37 +/- 0.37 to 3.28 +/- 0.52 mg/kg/min, p < 0.004), increased VO(2max) (p < 0.009), and decreased body weight (p < 0.009). Despite similar caloric intakes (1,816 +/- 128 vs. 1,610 +/- 100 kcal/day), dietary glycemic load trended towards a decrease during the study (140 +/- 10 g before, vs. 115 +/- 8 g during, p < 0.04). The change in insulin sensitivity correlated with the change in glycemic load (r = 0.84, p < 0.009). Four subjects reduced their glycemic load by 61 +/- 8%, and had significantly greater increases in insulin sensitivity (78 +/- 11 vs. 23 +/- 8%, p < 0.003), and decreases in body weight (p < 0.004) and plasma triglycerides (p < 0.04) compared to the rest of the group. CONCLUSION: The data suggest that combining a low-glycemic diet with exercise may provide an alternative and more effective treatment for insulin resistance in older obese adults. |
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Authors:
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John P Kirwan; Hope Barkoukis; Latina M Brooks; Christine M Marchetti; Bradley P Stetzer; Frank Gonzalez |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-16 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 55 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-02-19 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 326-33 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. kirwanj@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Body Mass Index Combined Modality Therapy / statistics & numerical data Diabetes Mellitus / prevention & control Diet Dietary Carbohydrates* Exercise / physiology* Female Glucose Clamp Technique Glycemic Index* Humans Insulin Resistance / physiology* Lipids / blood Male Obesity / complications, physiopathology, therapy* Oxygen Consumption Physical Fitness |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG12834/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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