| Exercise tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis. | |
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MedLine Citation:
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PMID: 20447647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Six months after acute infectious mononucleosis (IM), 13% of adolescents meet criteria for chronic fatigue syndrome (CFS). We measured exercise tolerance in adolescents with CFS and control subjects 6 months after IM. STUDY DESIGN: Twenty-one adolescents with CFS 6 months after IM and 21 recovered control subjects performed a maximal incremental exercise tolerance test with breath-by-breath gas analysis. Values expressed are mean+/-standard deviation. RESULTS: The adolescents diagnosed with CFS and control subjects did not differ in age, weight, body mass index, or peak work capacity. Lower oxygen consumption peak percent of predicted was seen in adolescents with CFS compared with control subjects (CFS 99.3+/-16.6 vs control subject 110.7+/-19.9, P=.05). Peak oxygen pulse also was lower in adolescents with CFS compared with recovered control subjects (CFS 12.4+/-2.9 vs control subjects 14.9+/-4.3, P=.03). CONCLUSIONS: Adolescents with CFS 6 months after IM have a lower degree of fitness and efficiency of exercise than recovered adolescents. Whether these abnormal exercise findings are a cause or effect of CFS is unknown. IM can lead to both fatigue and measurable changes in exercise testing in a subset of adolescents. |
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Authors:
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Ben Z Katz; Steven Boas; Yukiko Shiraishi; Cynthia J Mears; Renee Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-06 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 157 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-09-23 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 468-72, 472.e1 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Northwestern University, Feinberg School of Medicine and Children's Memorial Hospital, Chicago, IL 60614, USA. bkatz@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Exercise Tolerance* Fatigue Syndrome, Chronic / etiology*, physiopathology* Female Humans Infectious Mononucleosis / complications* Male Prospective Studies Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD043301-05/HD/NICHD NIH HHS; R01HD4330101A1/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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