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Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-induced Obese Mice.
MedLine Citation:
PMID:  22543735     Owner:  NLM     Status:  Publisher    
PURPOSE: Obesity has been shown to impair cutaneous wound healing which is associated with increased wound inflammation. Exercise is known to decrease obesity-associated inflammation and has been shown to speed cutaneous wound healing in aged mice. Therefore, we investigated whether treadmill exercise could speed cutaneous wound healing in obese, high-fat diet-fed mice. METHODS: We fed female C57Bl/6J mice a high fat diet (45% calories from fat) for 16 weeks to induce a state of obesity and insulin resistance. Mice then ran on a treadmill for 3 days prior to excisional wounding. On day 4, mice were wounded 1h after exercise. Mice then exercised for 5 days post-wounding, and healing was assessed by photoplanimetry for 10 days. RESULTS: As described previously, obesity impaired wound healing, with significantly larger wound sizes measured from days 3 to day 10 post-wounding (p<0.05). Exercise did not improve healing in lean mice fed a normal chow diet. However, wound size was significantly smaller in exercised obese mice compared to their lean counterparts (p<0.05 at day 1, day 4, day 5 post-wound). Surprisingly, we were unable to detect any differences in gene or protein expression of pro-inflammatory cytokines IL-1β and TNF-α or the anti-inflammatory cytokine IL-10 in the wounds. Likewise, there were no differences in gene expression of chemokines MCP-1 and KC or of growth factor PDGF in wounds of exercise and sedentary mice. CONCLUSION: This suggests an effect of exercise independent of alterations in inflammation. Future work should focus on early events post-wounding, including exercise effects on hemostasis and myofibroblast function.
Brandt D Pence; Luisa A Dipietro; Jeffrey A Woods
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-24
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Kinesiology & Community Health, 2Integrative Immunology & Behavior Program, University of Illinois at Urbana-Champaign, Urbana, IL; 3College of Dentistry, 4Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, IL; 5Division of Nutritional Sciences, 6Department of Pathology, University of Illinois at Urbana-Champaign, Urbana, IL.
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