Document Detail


Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia.
MedLine Citation:
PMID:  22966149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maintaining and improving fitness are associated with a lower risk of premature death from cardiovascular disease. Patients with schizophrenia are known to exercise less and have poorer health behaviors than average. Physical fitness and physiological regulation during exercise tasks have not been investigated to date among patients with schizophrenia. We studied autonomic modulation in a stepwise exhaustion protocol in 23 patients with schizophrenia and in matched controls, using spirometry and lactate diagnostics. Parameters of physical capacity were determined at the aerobic, anaerobic, and vagal thresholds (VT), as well as for peak output. VT was correlated with psychopathology, as assessed by the Positive and Negative Syndrome Scale, with the inflammatory markers IL-1β, IL-6, and TNF-α and with peak output. The MANOVA for heart and breathing rates, as well as for vagal modulation and complexity behavior of heart rate, indicated a profound lack of vagal modulation at all intensity levels, even after the covariate carbon monoxide concentration was introduced as a measure of smoking behavior. Significantly decreased physical capacity was demonstrated at the aerobic, anaerobic, and VT in patients. After the exercise task, reduced vagal modulation in patients correlated negatively with positive symptoms and with levels of IL-6 and TNF-α. This study shows decreased physical capacity in patients with schizophrenia. Upcoming intervention studies need to take into account the autonomic imbalance, which might predispose patients to arrhythmias during exercise. Results of inflammatory parameters are suggestive of a reduced activity of the anti-inflammatory cholinergic pathway in patients, leading to a pro-inflammatory state.
Authors:
Stefanie Ostermann; Marco Herbsleb; Steffen Schulz; Lars Donath; Sandy Berger; Daniela Eisenträger; Tobias Siebert; Hans-Josef Müller; Christian Puta; Andreas Voss; Holger W Gabriel; Kathrin Koch; Karl-Jürgen Bär
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Publication Detail:
Type:  Journal Article     Date:  2012-09-10
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  39     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-30     Completed Date:  2014-04-22     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-49     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System Diseases / complications,  physiopathology*
Exercise Test / methods*
Female
Heart Rate / physiology
Humans
Inflammation / immunology*
Male
Physical Fitness / physiology*
Psychiatric Status Rating Scales
Schizophrenia / immunology,  physiopathology*
Spirometry
Vagus Nerve / physiopathology
Young Adult
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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