| Exercise-Related QT Interval Shortening with a Peaked T Wave in a Healthy Boy with a Family History of Sudden Cardiac Death. | |
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MedLine Citation:
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PMID: 22433001 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An asymptomatic 15-year-old boy, who had a family history of sudden cardiac death, was referred for screening for cardiac disease. The 12-lead electrocardiogram at rest showed a short QT/QTc(Bazett)/QTc(Fredericia) interval of 320/388/364 ms, but the intervals were further shortened to 200/339/284 ms after the treadmill test concomitant with appearance of a peaked T wave. Other conventional cardiac examinations were normal, but effective refractory period was less than 180 ms in both ventricles, and double ventricular extrastimulation reproducibly induced nonsustained polymorphic ventricular tachycardia. Intravenous administration of epinephrine also induced a short QT interval and a peaked T wave, and a hump was manifested on the T wave of the first postpacing beat with a longer preceding R-R interval. Furthermore, a couple of premature ventricular complexes originated from a similar timing as the hump. Genetic analysis did not show the mutation in KCNQ1, KCNH2, KCNE1, KCNE2, KCNJ2, SCN5A genes but revealed single nucleotide polymorphism (C5457T) in SCN5A gene. (PACE 2012;xx:e1-e4). |
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Authors:
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Masaomi Chinushi; Akinori Sato; Kenichi Iijima; Katuya Suzuki; Furushima Hiroshi; Daisuke Izumi; Hiroshi Watanabe; Hasegawa Kanae; Yoshifusa Aizawa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-20 |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: - ISSN: 1540-8159 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc. |
Affiliation:
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School of Health Science, Niigata, Japan First Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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