Document Detail

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.
MedLine Citation:
PMID:  21148807     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD).
METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and 2) MDD status (depressed; partial remission; full remission) in 172 available participants (85% of the original cohort). Regression analyses were performed to examine the effects of treatment group assignment, as well as follow-up antidepressant medication use and self-reported exercise (Godin Leisure-Time Exercise Questionnaire), on the two outcomes.
RESULTS: In the original study, patients receiving exercise achieved similar benefits compared with those receiving sertraline. At the time of the 1-year follow-up, rates of MDD remission increased from 46% at post treatment to 66% for participants available for follow-up. Neither initial treatment group assignment nor antidepressant medication use during the follow-up period were significant predictors of MDD remission at 1 year. However, regular exercise during the follow-up period predicted both Hamilton Depression Rating Scale scores and MDD diagnosis at 1 year. This relationship was curvilinear, with the association concentrated between 0 minute and 180 minutes of weekly exercise.
CONCLUSION: The effects of aerobic exercise on MDD remission seem to be similar to sertraline after 4 months of treatment; exercise during the follow-up period seems to extend the short-term benefits of exercise and may augment the benefits of antidepressant use.
TRIAL REGISTRATION: Identifier: NCT00331305.
Benson M Hoffman; Michael A Babyak; W Edward Craighead; Andrew Sherwood; P Murali Doraiswamy; Michael J Coons; James A Blumenthal
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-10
Journal Detail:
Title:  Psychosomatic medicine     Volume:  73     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:    2011 Feb-Mar
Date Detail:
Created Date:  2011-02-10     Completed Date:  2011-04-12     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
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MeSH Terms
Antidepressive Agents / therapeutic use*
Depressive Disorder, Major / diagnosis,  drug therapy,  therapy*
Diagnostic and Statistical Manual of Mental Disorders
Follow-Up Studies
Logistic Models
Middle Aged
Psychiatric Status Rating Scales / statistics & numerical data
Sertraline / therapeutic use*
Social Support
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Antidepressive Agents; QUC7NX6WMB/Sertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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