| Exercise and Pharmacotherapy in Patients With Major Depression: One-Year Follow-Up of the SMILE Study. | |
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MedLine Citation:
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PMID: 21148807 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). Methods: In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and 2) MDD status (depressed; partial remission; full remission) in 172 available participants (85% of the original cohort). Regression analyses were performed to examine the effects of treatment group assignment, as well as follow-up antidepressant medication use and self-reported exercise (Godin Leisure-Time Exercise Questionnaire), on the two outcomes. Results: In the original study, patients receiving exercise achieved similar benefits compared with those receiving sertraline. At the time of the 1-year follow-up, rates of MDD remission increased from 46% at post treatment to 66% for participants available for follow-up. Neither initial treatment group assignment nor antidepressant medication use during the follow-up period were significant predictors of MDD remission at 1 year. However, regular exercise during the follow-up period predicted both Hamilton Depression Rating Scale scores and MDD diagnosis at 1 year. This relationship was curvilinear, with the association concentrated between 0 minute and 180 minutes of weekly exercise. Conclusion: The effects of aerobic exercise on MDD remission seem to be similar to sertraline after 4 months of treatment; exercise during the follow-up period seems to extend the short-term benefits of exercise and may augment the benefits of antidepressant use. |
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Authors:
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Benson M Hoffman; Michael A Babyak; W Edward Craighead; Andrew Sherwood; P Murali Doraiswamy; Michael J Coons; James A Blumenthal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-10 |
Journal Detail:
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Title: Psychosomatic medicine Volume: - ISSN: 1534-7796 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Psychiatry and Behavioral Sciences (B.M.H., M.A.B., A.S., M.J.C., J.A.B.), Duke University Medical Center, Durham, North Carolina; and the Department of Psychology (W.E.C.), Emory University, Atlanta, Georgia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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