| Exercise for people in early- or mid-stage Parkinson disease: a 16-month randomized controlled trial. | |
| | |
MedLine Citation:
|
PMID: 22822237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Exercise confers short-term benefits for individuals with Parkinson disease (PD). OBJECTIVE: The purpose of the study was to compare short- and long-term responses among 2 supervised exercise programs and a home-based control exercise program. DESIGN: The 16-month randomized controlled exercise intervention investigated 3 exercise approaches: flexibility/balance/function exercise (FBF), supervised aerobic exercise (AE), and home-based exercise (control). SETTING: This study was conducted in outpatient clinics. PATIENTS: The participants were 121 individuals with PD (Hoehn & Yahr stages 1-3). INTERVENTIONS: The FBF program (individualized spinal and extremity flexibility exercises followed by group balance/functional training) was supervised by a physical therapist. The AE program (using a treadmill, bike, or elliptical trainer) was supervised by an exercise trainer. Supervision was provided 3 days per week for 4 months, and then monthly (16 months total). The control group participants exercised at home using the National Parkinson Foundation Fitness Counts program, with 1 supervised, clinic-based group session per month. MEASUREMENTS: Outcomes, obtained by blinded assessors, were determined at 4, 10, and 16 months. The primary outcome measures were overall physical function (Continuous Scale-Physical Functional Performance [CS-PFP]), balance (Functional Reach Test [FRT]), and walking economy (oxygen uptake [mL/kg/min]). Secondary outcome measures were symptom severity (Unified Parkinson's Disease Rating Scale [UPDRS] activities of daily living [ADL] and motor subscales) and quality of life (39-item Parkinson's Disease Quality of Life Scale [PDQ-39]). RESULTS: Of the 121 participants, 86.8%, 82.6%, and 79.3% completed 4, 10, and 16 months, respectively, of the intervention. At 4 months, improvement in CS-PFP scores was greater in the FBF group than in the control group (mean difference=4.3, 95% confidence interval [CI]=1.2 to 7.3) and the AE group (mean difference=3.1, 95% CI=0.0 to 6.2). Balance was not different among groups at any time point. Walking economy improved in the AE group compared with the FBF group at 4 months (mean difference=-1.2, 95% CI=-1.9 to -0.5), 10 months (mean difference=-1.2, 95% CI=-1.9 to -0.5), and 16 months (mean difference=-1.7, 95% CI=-2.5 to -1.0). The only secondary outcome that showed significant differences was UPDRS ADL subscale scores: the FBF group performed better than the control group at 4 months (mean difference=-1.47, 95% CI=-2.79 to -0.15) and 16 months (mean difference=-1.95, 95% CI=-3.84 to -0.08). LIMITATIONS: Absence of a non-exercise control group was a limitation of the study. CONCLUSIONS: Findings demonstrated overall functional benefits at 4 months in the FBF group and improved walking economy (up to 16 months) in the AE group. |
| | |
Authors:
|
Margaret Schenkman; Deborah A Hall; Anna E Barón; Robert S Schwartz; Pamela Mettler; Wendy M Kohrt |
Related Documents
:
|
15715687 - Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle e... 15209647 - Physical activity, exercise, and inflammatory markers in older adults: findings from th... 8911827 - Glutathione-dependent modulation of exhausting exercise-induced changes in neutrophil f... 16175497 - Oxidants, antioxidants in physical exercise and relation to thyroid function. 2234287 - Effect of exercise on physiological age-related change at mouse neuromuscular junctions. 3094567 - An end-tidal sampler for use with slow response analysers during anaesthesia. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-07-19 |
Journal Detail:
|
Title: Physical therapy Volume: 92 ISSN: 1538-6724 ISO Abbreviation: Phys Ther Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-05 Completed Date: 2013-01-09 Revised Date: 2013-05-02 |
Medline Journal Info:
|
Nlm Unique ID: 0022623 Medline TA: Phys Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 1395-410 Citation Subset: AIM; IM |
Affiliation:
|
Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado Anschutz Medical Campus, Mailstop C-244, 13121 E 17th Ave, ED II South, Room L28-3106, Aurora, CO 80045, USA. margaret.schenkman@ucdenver.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT01257945 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Activities of Daily Living* Disability Evaluation Exercise Therapy / methods* Female Humans Male Parkinson Disease / physiopathology, rehabilitation* Physical Therapy Modalities Postural Balance Quality of Life* Severity of Illness Index Treatment Outcome Walking |
| Grant Support | |
ID/Acronym/Agency:
|
NS052487/NS/NINDS NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; R01 HD043770-04/HD/NICHD NIH HHS; TL1 RR025778/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Personal Health Behaviors and Role-Modeling Attitudes of Physical Therapists and Physical Therapist ...
Next Document: Factors Associated With Physical Therapy Services Received for Individuals With Cerebral Palsy in an...