| Exercise paradigms to study brain injury recovery in rodents. | |
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MedLine Citation:
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PMID: 21273898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise has been found to influence molecular systems important for maintaining neural function and plasticity as well as treatment of neurologic disorders. The stimuli required to elicit plasticity are thought to be activity dependent. Several protocols of physical exercise have been used to explore its effects on brain function. However, it is becoming increasingly recognized that no single physical exercise model is likely to fulfill all therapeutic needs. Varied interpretations of data derived from animal models have given rise to the lack of uniformity in the description and control of various features of the physical exercise stimulus, ranging from low to high intensity, intermittent to sustained, short to long durations, and different modes of activity. This article first describes the characteristics of the most frequently used animal models and goes on to review brain plasticity in intact animals and the usefulness of these models for the study of brain disorders. In this regard, animal models that investigate the beneficial effects of exercise on the brain before and after brain injury are discussed. A challenge for future studies is to better evaluate the usefulness of physical exercise protocols for preventing or treating brain disorders. |
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Authors:
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Ricardo Mario Arida; Fulvio Alexandre Scorza; Sérgio Gomes da Silva; Roberta Monterazzo Cysneiros; Esper Abrão Cavalheiro |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: 90 ISSN: 1537-7385 ISO Abbreviation: Am J Phys Med Rehabil Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-18 Completed Date: 2011-09-14 Revised Date: 2011-09-15 |
Medline Journal Info:
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Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 452-65 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Universidade Federal de São Paulo, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries / complications, metabolism, physiopathology, rehabilitation* Disease Models, Animal Exercise Test Female Male Mice Neurodegenerative Diseases / etiology, prevention & control* Physical Conditioning, Animal / methods* Random Allocation Rats Rats, Sprague-Dawley Recovery of Function / physiology* Risk Assessment Rodentia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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