Document Detail


Exercise and the metabolic syndrome with weight regain.
MedLine Citation:
PMID:  20167668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Weight loss improves metabolic syndrome (MetS) factors, but risk may return with weight regain. This study was designed to determine if exercise training can maintain improvements in MetS risk factors during weight regain. In a randomized control trial,102 overweight or obese (body mass index 25.0-39.9 kg/m(2)) men and women (age 21-52 yr), with characteristics of the MetS, lost 10% of body weight with supervised walking/jogging at 60% of maximal oxygen consumption (Vo(2 max)) (-400 kcal/session), 5 days/wk, and caloric restriction (-600 kcal/day) over a 4- to 6-mo period. After weight loss, 77 remaining subjects underwent programmed weight regain (+50% of lost weight) for 4-6 mo with random assignment to two groups: no exercise (NoEX) or continued supervised exercise (EX). Blood pressure, regional fat, glucose homeostasis, lipids, and inflammatory markers were assessed at baseline, post-weight loss, and post-weight regain. Groups were compared by two-way repeated-measures ANOVA on the 67 subjects. After weight loss (9.7 +/- 0.2% of body weight), significant (P < 0.05) improvements were observed in almost all parameters assessed. Following weight regain (54.4 +/- 1.6% of lost weight), the NoEX group exhibited deterioration in most metabolic markers, while the EX group maintained improvements in Vo(2 max), blood pressures, glucose homeostasis, high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), oxidized LDL, and other markers of inflammation, but did not maintain improvements in triglyceride and cholesterol concentrations or abdominal fat. Results of this design of controlled human weight regain suggest that aerobic exercise can counter the detrimental effects of partial weight regain on many markers of disease risk.
Authors:
Tom R Thomas; Shana O Warner; Kevin C Dellsperger; Pamela S Hinton; Adam T Whaley-Connell; R Scott Rector; Ying Liu; Melissa A Linden; Anand Chockalingam; John P Thyfault; David R Huyette; Ze Wang; Richard H Cox
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-02-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-10     Citation Subset:  IM    
Affiliation:
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA. thomastr@missouri.edu
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / physiopathology
Adult
Blood Glucose / physiology
Blood Pressure / physiology
Body Weight / physiology
Caloric Restriction
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Exercise / physiology*
Female
Humans
Lipids / blood
Male
Metabolic Syndrome X / physiopathology,  therapy*
Middle Aged
Obesity / physiopathology
Oxygen Consumption / physiology
Weight Gain / physiology*
Weight Loss / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
R01-DK-067036/DK/NIDDK NIH HHS; T32-AR-048523/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2010 Jul;109(1):1-2   [PMID:  20395547 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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