| Exercise limits the production of endothelin in the coronary vasculature. | |
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MedLine Citation:
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PMID: 21317308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously demonstrated that endothelin (ET)-mediated coronary vasoconstriction wanes with increasing exercise intensity via a nitric oxide- and prostacyclin-dependent mechanism (Ref. 23). Therefore, we hypothesized that the waning of ET coronary vasoconstriction during exercise is the result of decreased production of ET and/or decreased ET receptor sensitivity. We investigated coronary ET receptor sensitivity using intravenous infusion of ET and coronary ET production using intravenous infusion of the ET precursor Big ET, at rest and during continuous treadmill exercise at 3 km/h in 16 chronically instrumented swine. In the systemic vasculature, Big ET and ET induced similar changes in hemodynamic parameters at rest and during continuous exercise at 3 km/h, indicating that exercise does not alter ET production or receptor sensitivity in the systemic vasculature. In the coronary vasculature, infusion of ET resulted in similar dose-dependent decreases in coronary blood flow and coronary venous oxygen tension and saturation at rest and during exercise. In contrast, administration of Big ET resulted in dose-dependent decreases in coronary blood flow, as well as coronary venous oxygen tension and saturation at rest. These effects of Big ET were significantly reduced during exercise. Altogether, our data indicate that continuous exercise at 3 km/h attenuates ET-mediated coronary vasoconstriction through reduced production of ET from Big ET rather than through reduced ET sensitivity of the coronary vasculature. The decreased ET production during exercise likely contributes to metabolic coronary vasodilation. |
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Authors:
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Vincent J de Beer; Shawn B Bender; Yannick J Taverne; Fen Gao; Dirk J Duncker; M Harold Laughlin; Daphne Merkus |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-11 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-07-07 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1950-9 Citation Subset: IM |
Affiliation:
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Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, he Netherlands. d.merkus@erasmusmc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / metabolism* Dose-Response Relationship, Drug Endothelins / metabolism*, pharmacology Hemodynamics / physiology Models, Animal Physical Conditioning, Animal / physiology* Receptors, Endothelin / metabolism Regional Blood Flow / drug effects, physiology Swine Vasoconstriction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AR-048523/AR/NIAMS NIH HHS; HL-52490/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Receptors, Endothelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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