| Exercise Intensity and Lymphocyte Subset Apoptosis. | |
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MedLine Citation:
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PMID: 23041963 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This investigation assessed the lymphocyte subset response to increasing intensity. Participants completed an exertion test (VO2max), and later performed a 10-min run at 76% VO2max, 5-min at 87%, and run to exhaustion at 100% intensity. Blood was sampled at rest, following each intensity, and 1-h post. Cell concentration, apoptosis (annexin V) and migration (CX3CR1) were evaluated in CD4+, CD8+, and CD19+ subsets. Relative data were analyzed using 1-way ANOVA with significance at P≤0.05. Absolute changes from rest (Δ baseline) were calculated for exercise conditions. CX3CR1 displayed relative changes 1-h post, (CD8+ Pre=58%, Post=68%, 1 h-Post=37%, P=0.04) (CD19+ Pre=1.9%, Post=3.2%, 1 h-Post=5.2%, P=0.02). No relative changes were noted for subsets and annexin V. Absolute changes revealed that CD4+/annexin V+ and CD8+/annexin V+ significantly increased at 76%,(P<0.01). Significant absolute increases were observed in CD4+/CX3CR1 at 87% VO2max, and at 87% and 100% VO2max in CD8+/CX3CR1 (P<0.01). Subsets respond differently with intensity with respect to cell count, and markers of apoptosis and cell migration. CD4+ and CD8+ appear to be prone to apoptosis with moderate exercise, but significant increases in migration at higher intensities suggests movement of these cells from the vasculature in postexercise measurements. |
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Authors:
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J W Navalta; S Lyons; J Prestes; S W Arnett; M Schafer; G L Sobrero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: International journal of sports medicine Volume: - ISSN: 1439-3964 ISO Abbreviation: Int J Sports Med Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, Las Vegas, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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