| Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine. | |
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MedLine Citation:
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PMID: 21068158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Follistatin is a member of the TGF-β super family and inhibits the action of myostatin to regulate skeletal muscle growth. The regulation of follistatin during physical exercise is unclear but may be important because physical activity is a major intervention to prevent age-related sarcopenia. First, healthy subjects performed either bicycle or one-legged knee extensor exercise. Arterial-venous differences were assessed during the one-legged knee extensor experiment. Next, mice performed 1 h of swimming, and the expression of follistatin was examined in various tissues using quantitative PCR. Western blotting assessed follistatin protein content in the liver. IL-6 and epinephrine were investigated as drivers of follistatin secretion. After 3 h of bicycle exercise, plasma follistatin increased 3 h into recovery with a peak of 7-fold. No net release of follistatin could be detected from the exercising limb. In mice performing a bout of swimming exercise, increases in plasma follistatin as well as follistatin mRNA and protein expression in the liver were observed. IL-6 infusion to healthy young men did not affect the follistatin concentration in the circulation. When mice were stimulated with epinephrine, no increase in the hepatic mRNA of follistatin was observed. This is the first study to demonstrate that plasma follistatin is increased during exercise and most likely originates from the liver. These data introduce new perspectives regarding muscle-liver cross talk during exercise and during recovery from exercise. |
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Authors:
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Jakob Hansen; Claus Brandt; Anders R Nielsen; Pernille Hojman; Martin Whitham; Mark A Febbraio; Bente K Pedersen; Peter Plomgaard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-10 |
Journal Detail:
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Title: Endocrinology Volume: 152 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 164-71 Citation Subset: AIM; IM |
Affiliation:
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Centre of Inflammation and Metabolism, Faculty of Health Sciences, University of Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Cell Line Exercise / physiology* Female Follistatin / blood*, metabolism Humans Liver / metabolism Male Mice Muscle Contraction / physiology* Muscle, Skeletal / metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Follistatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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