Document Detail


Exercise-Induced ST Elevation in Patients With Non-Ischemic Dilated Cardiomyopathy and Narrow QRS Complexes.
MedLine Citation:
PMID:  23291994     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The clinical significance and prevalence of exercise-induced ST elevation (ESTE) in non-ischemic dilated cardiomyopathy (NIDCM) patients are unknown. Methods and Results: We retrospectively examined 12-lead ECGs during cardiopulmonary exercise testing in 360 consecutive NIDCM patients (left ventricular ejection fraction (LVEF) <45%) with narrow QRS. ESTE was defined as ≥1.0mm ST (J-point) elevation compared with baseline. During long-term follow-up for major cardiac events (death, transplantation, or LV assist device implantation), ESTE was recognized in 50 patients (14%). They had much lower LVEF than patients without ESTE (20±7% vs. 27±7%, respectively, P<0.001), whereas the differences in peak VO(2) (P=0.01) and VE/VCO(2) slope (P=0.04) were relatively small. Major cardiac events occurred more frequently in patients with ESTE than in those without ESTE (39% vs. 12% at 48 months). Increased event rates were associated with low peak VO(2) (<14ml·min(-1)·kg(-1)) in patients without ESTE (39% vs. 23%, P<0.05), but not in those with ESTE (50% vs. 62%, NS). Cox multivariate analysis revealed ESTE as the strongest independent prognosticator among exercise parameters (hazard ratio: 2.41 [95% confidence interval 1.03-5.63], P<0.05). Conclusions: A substantial number of NIDCM patients exhibit ESTE, which indicates a poor prognosis. Low peak VO(2) and ESTE may reflect different aspects of the pathophysiological processes that deteriorate heart failure.
Authors:
Hiroyuki Takahama; Hiroshi Takaki; Yusuke Sata; Kazushi Sakane; Yasushi Ino; Teruo Noguchi; Yoichi Goto; Masaru Sugimachi
Related Documents :
1147874 - Instrumented personal exercise during long-duration space flights.
24436354 - Dietary nitrate does not improve repeated sprint performance.
23932354 - Focal task-specific lower extremity dystonia associated with intense repetitive exercis...
22310514 - Acute effects of countermovement jumping and sprinting on shot put performance.
3054354 - Exercise and diabetes mellitus.
10642384 - Preexercise medium-chain triglyceride ingestion does not alter muscle glycogen use duri...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-29
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Ou...
Next Document:  Myocardial Layer-Specific Effect of Myoblast Cell-Sheet Implantation Evaluated by Tissue Strain Imag...