Document Detail


Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment.
MedLine Citation:
PMID:  22914593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Post-trial pharmacological activation of the noradrenergic system can facilitate memory consolidation. Because exercise activates the locus coeruleus and increases brain norepinephrine release, we hypothesized that post-trial exercise could function as a natural stimulus to enhance memory consolidation. We investigated this in amnestic mild cognitive impairment (aMCI) and cognitively normal elderly individuals by examining the effects of an acute bout of post-learning, aerobic exercise (6 minutes at 70% VO2 max on a stationary bicycle) on memory for some emotional images. Exercise significantly elevated endogenous norepinephrine (measured via the biomarker, salivary alpha-amylase) in both aMCI patients and controls. Additionally, exercise retrogradely enhanced memory in both aMCI patients and controls. Acute exercise that activates the noradrenergic system may serve as a beneficial, natural, and practical therapeutic intervention for cognitive decline in the aging population.
Authors:
Sabrina K Segal; Carl W Cotman; Lawrence F Cahill
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  32     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-08-23     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1011-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Neurons / metabolism
Aged
Aging / metabolism*
Amnesia / metabolism,  psychology,  therapy
Exercise / physiology*
Female
Humans
Male
Mild Cognitive Impairment / metabolism*,  psychology,  therapy
Norepinephrine / metabolism*
Salivary alpha-Amylases / analysis,  metabolism*
Grant Support
ID/Acronym/Agency:
575082//PHS HHS; AG016573/AG/NIA NIH HHS; R01 AG034667/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
EC 3.2.1.1/Salivary alpha-Amylases; X4W3ENH1CV/Norepinephrine
Comments/Corrections

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