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Exercise-Induced IGF-I System Concentrations after Training in Women.
MedLine Citation:
PMID:  23034644     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: This study examined the effects of short-term physical training on the acute hormonal response (i.e. growth hormone [GH], total and free IGF-I, and IGFBP-1, -2, and -3) to resistance exercise (RE) in women. METHODS: Forty six women (20.3 ± 0.3 y, mass 64.1 ± 7.3 kg, height 165.7 ± 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R+E), or control (C) group for 8 weeks. Subjects completed a standardized bout of resistance exercise (six sets of back squats at 10-RM) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately post-exercise (POST), and at 15 min and 30 min after exercise. RESULTS: Acute RE significantly increased (p < 0.05) serum GH (mean ± SD; change from PRE to POST; +10.9 ± 7.5 µg·l), total IGF-I (+66.1 ± 25.4 µg·l), IGFBP-1 (+2.5 ± 3.1 µg·l), IGFBP-2 (+86.0 ± 86.8 µg·l), and IGFBP-3 (+0.69 ± 0.25 mg·l) concentrations and decreased free IGF-I concentrations (-0.14 ± 0.21 µg·l). Following 8 weeks of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8: +82.5 ± 120.8 µg·l) and IGFBP-1 concentrations were significantly decreased (-6.7 ± 13.6 µg·l) during exercise in groups that participated in resistance training (R and R+E); no significant changes were seen following E or C. CONCLUSIONS: Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute resistance exercise, indicating exercise mode-specific adaptations in the circulating IGF-I system.
Authors:
Sara M Gregory; Barry A Spiering; Joseph A Alemany; Alexander P Tuckow; Kevin R Rarick; Jeffery S Staab; Disa L Hatfield; William J Kraemer; Carl M Maresh; Bradley C Nindl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA; 2Deparment of Exercise and Sports Studies, Springfield College, Springfield, MA; 3Department of Kinesiology, University of Connecticut, Storrs, CT; 4Department of Exercise Science, University of South Carolina, SC, 5Department of Kinesiology, University of Rhode Island, RI.
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