Document Detail

Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy.
MedLine Citation:
PMID:  23110946     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess for exercise-induced bronchoconstriction in 8- to 12-year-old children who had chronic lung disease (CLD) in infancy, and to evaluate the response of bronchoconstriction to bronchodilation with albuterol in comparison with preterm and term controls.
STUDY DESIGN: Ninety-two children, including 29 with CLD, 33 born preterm at ≤32 weeks' gestation, and 30 born at term, underwent lung spirometry before and after cycle ergometry testing and after postexercise bronchodilation with albuterol.
RESULTS: Doctor-diagnosed asthma and exercise-induced wheeze were reported more frequently in the CLD group than in the preterm and term groups, but only 10% were receiving a bronchodilator. There were no differences among the groups in peak minute ventilation, oxygen uptake, or carbon dioxide output at maximum exercise. After maximal exercise, predicted forced expiratory volume in 1 second (FEV1) decreased from a mean baseline value of 81.9% (95% CI, 76.6-87.0%) to 70.8% (95% CI, 65.5-76.1%) after exercise in the CLD group, from 92.0% (95% CI, 87.2-96.8%) to 84.3% (95% CI, 79.1-89.4%) in the preterm group, and from 97.5% (95% CI, 92.5-102.6%) to 90.3% (95% CI, 85.1-95.5%) in the term group. After albuterol administration, FEV1 increased to 86.8% (95% CI, 81.7-92.0%) in the CLD group, 92.1% (95% CI, 87.3-96.9%) in the preterm group, and 97.1% (95% CI, 92.0-102.3%) in the term group. The decrease in predicted FEV1 after exercise and increase in predicted FEV1 after bronchodilator use were greatest in the CLD group (-11.0% [95% CI, -18.4 to -3.6%] and 16.0% [95% CI, 8.6-23.4%], respectively; P < .005 for both), with differences of <8% in the 2 control groups.
CONCLUSION: School-age children who had CLD in infancy had significant exercise-induced bronchoconstriction that responded significantly to bronchodilation. Reversible exercise-induced bronchoconstriction is common in children who experienced CLD in infancy and should be actively assessed for and treated.
Suchita Joshi; Thomas Powell; William J Watkins; Mark Drayton; E Mark Williams; Sailesh Kotecha
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Publication Detail:
Type:  Journal Article     Date:  2012-10-27
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-05-16     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-818.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom.
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MeSH Terms
Albuterol / therapeutic use
Asthma, Exercise-Induced / drug therapy
Bronchoconstriction / drug effects*
Bronchodilator Agents / therapeutic use
Forced Expiratory Volume / drug effects
Infant, Newborn
Lung / pathology
Lung Diseases / complications,  physiopathology*
Respiratory Function Tests
Respiratory Sounds
Spirometry / methods
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol
Erratum In:
J Pediatr. 2013 Jun;162(6):1298

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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