| Exercise-Induced Adaptations of Cardiac Redox Homeostasis and Remodelling in Heterozygous SOD2-Knockout mice. | |
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MedLine Citation:
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PMID: 21836049 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A reduced expression of the manganese-dependent superoxide dismutase (SOD2) is characterised by increased cardiac oxidative stress. Oxidative stress has also been described in situations of physical exercise. We investigated the influence of physical exercise (EX, treadmill 1 h a day at 15 m/min, 5 days/week, at an angle of 5° for a duration of 8 weeks) on cardiac function (heart frequency (HF), echocardiography, morphometry), oxidative stress (reactive oxygen species (ROS)) and antioxidative defence capacity (peroxiredoxin 1-6) in male SOD2-knockout (SOD2_EX) and wild-type mice (WT_EX) compared to untrained age-matched animals (WT_CON; SOD2_CON). In SOD2_CON, heart weight, cardiomyocyte diameter and cardiac ROS were significantly larger and peroxiredoxin-isoforms 4-6 lower than in WT_CON. The vessels-per-cardiomyocyte ratio, cardiac VEGF-concentration and cardiac function were similar in SOD2_CON and WT_CON. Both groups tolerated the exercise protocol well. In WT, exercise significantly increased vessels-per-cardiomyocyte ratio and ROS-generation and down-regulated peroxiredoxin isoforms 4-6 and VEGF-generation. The vessels-per-cardiomyocyte ratio, cardiac VEGF concentration and cardiac ROS were not altered in SOD2_EX compared to SOD2_CON but a significant up-regulation of cardiac peroxiredoxin 1 and 4 was observed. Similar to the result observed in WT_EX, peroxiredoxin 3 was up-regulated in SOD2_EX. Chronic exercise shifted the (mal)adaptive hypertrophic into a compensated dilated cardiac phenotype in SOD2_EX. Conclusions: Down-regulation of SOD2 induces a maladaptive cardiac hypertrophy. In this situation, physical exercise results in a further deterioration of cardiac remodelling despite an up-regulation of the antioxidative defense system. |
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Authors:
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Lisa Katharina Richters; Nadine Lange; Robert Renner; Nicolai Treiber; Alexander Ghanem; Klaus Tiemann; Karin Scharffetter-Kochanek; Wilhelm Bloch; Klara Brixius |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-11 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1German Sport University Cologne. |
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